Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin.
about
Development of recombinant hemoglobin-based oxygen carriersLigand Migration in the Apolar Tunnel of Cerebratulus lacteus Mini-HemoglobinBlocking the Gate to Ligand Entry in Human HemoglobinCharacterization of the estradiol-binding site structure of human protein disulfide isomerase (PDI)Electronic structure and dynamics of nitrosyl porphyrinsDetermination of ligand pathways in globins: apolar tunnels versus polar gates.Real-time tracking of CO migration and binding in the α and β subunits of human hemoglobin via 150-ps time-resolved Laue crystallographyKinetic spectroscopy of heme hydration and ligand binding in myoglobin and isolated hemoglobin chains: an optical window into heme pocket water dynamics.CO and O2 binding to pseudo-tetradentate ligand-copper(I) complexes with a variable N-donor moiety: kinetic/thermodynamic investigation reveals ligand-induced changes in reaction mechanism.Characterization of the estradiol-binding site structure of human pancreas-specific protein disulfide isomerase: indispensable role of the hydrogen bond between His278 and the estradiol 3-hydroxyl groupNew look at hemoglobin allostery.Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing proteinFamilial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu)).α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxideA hemoglobin variant associated with neonatal cyanosis and anemiaPost-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobinα-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond.Autoxidation and oxygen binding properties of recombinant hemoglobins with substitutions at the αVal-62 or βVal-67 position of the distal heme pocketRole of Heme Pocket Water in Allosteric Regulation of Ligand Reactivity in Human HemoglobinFive-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.Variations on the theme: allosteric control in hemoglobin.Modulating distal cavities in the α and β subunits of human HbA reveals the primary ligand migration pathway.Structures and oxygen affinities of crystalline human hemoglobin C (β6 Glu->Lys) in the R and R2 quaternary structuresAn atomistic view on human hemoglobin carbon monoxide migration processes.Unlocking the binding and reaction mechanism of hydroxyurea substrates as biological nitric oxide donorsProtonation of histidine 55 affects the oxygen access to heme in the alpha chain of the hemoglobin from the Antarctic fish Trematomus bernacchii.Novel Molecular Interactions of Acylcarnitines and Fatty Acids with Myoglobin.2017 Military Supplement: Current Challenges in the Development of Acellular Hemoglobin Oxygen Carriers by Protein Engineering.Hemoglobin Kirklareli (α H58L), a New Variant Associated with Iron Deficiency and Increased CO Binding.Exploring the Strength of the H-Bond in Synthetic Models for Heme Proteins: The Importance of the N-H Acidity of the Distal Base.Clues for discovering a new biological function of Vitreoscilla hemoglobin in organisms: potential sulfide receptor and storage.Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose.
P2860
Q27008891-7F462860-395D-4F8C-AE98-7099F1245C88Q27666315-2946F2C8-BB63-4E6F-B121-58D88874342CQ27666414-7FF8E18F-075F-4C94-97E5-8372FA5F5D69Q28477788-F4546A52-9E5A-44BD-A0AC-4B704E4E782EQ30474789-E26D4959-1947-4D65-934D-4FF6E242E7E9Q30525332-0FEC72A8-C26C-4200-A7B5-A6543796F672Q33607217-67D01C2D-4161-43AF-94BC-6005A8D6A830Q33644613-27952CFC-8B1E-42B2-90EE-F0C581CBDD8CQ33667207-6A3728A9-1E50-4F0B-88E1-2BF1E5304901Q34758159-AEA90F5B-D625-4EA0-88D1-81A437F41EC4Q35866992-3BFC444C-36BB-4D93-89C4-C71E2BAF19AAQ35879569-83C9F0BD-D572-49D2-8059-D49463A8D810Q35879658-4ED45178-FD41-4279-8BB3-7FEAEF8ED543Q36479773-29878B55-5D3C-4354-BD63-9B0C55511A62Q36596310-1BE5316B-3C34-46CF-9B70-3340AAFF5A4FQ36784035-819A70EE-B3DA-4E2F-AAB1-4843FC12C80FQ36888438-D84DA56E-9214-4FAD-9790-629D87040EB7Q37000641-86D9874F-5942-4B93-A5CB-FB66AE9A987EQ37132170-7BFA456C-AEE4-4ADB-A23A-91443333178EQ37162783-9A1511F5-7512-4AE0-9AD1-678A2905B636Q37550705-186F5E22-7314-4EDC-BD3B-D7157C165A23Q38155944-5ED52A3B-5A46-46A2-AD84-9DE6960CE8DFQ38256073-DB7B7D80-4BFA-4F7D-9E26-4F9345B59AB6Q38675032-0F3FC892-C2E5-41A8-A110-9067527BCF29Q41384613-34AE271F-A121-45AF-9664-D2843E9CB473Q41763205-E4543D9C-A155-43BD-92F0-8C4823D5A1A6Q43970102-46BA2D27-CF5D-4C5F-AF70-0C87C6AFFC4DQ45092518-9AFD68A8-5191-4725-82CE-2CF04AE2A01FQ46266772-19E52DAE-BEF0-4632-A837-BB9EF65BE470Q47909517-1EF2291C-C666-405A-B011-AF16210882C8Q48196537-C8CD3DD5-8162-4A43-B474-77A7E9C832A7Q51434753-B654CB6B-4285-40E2-BA69-30A36302CA2BQ55281743-DF5BDDC7-BB3F-4352-83BB-B1A00BABB426
P2860
Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@ast
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@en
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@nl
type
label
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@ast
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@en
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@nl
prefLabel
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@ast
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@en
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@nl
P2860
P356
P1476
Distal histidine stabilizes bo ...... its of adult human hemoglobin.
@en
P2093
Ivan Birukou
Rachel L Schweers
P2860
P304
P356
10.1074/JBC.M109.053934
P407
P577
2010-01-15T00:00:00Z