Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
about
High incidence of somatic BAP1 alterations in sporadic malignant mesotheliomaThe landscape of targeted therapies for cholangiocarcinoma: current status and emerging targetsGenetic profiling of intrahepatic cholangiocarcinoma and its clinical implication in targeted therapyAn Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of CholangiocarcinomaMediator kinase module and human tumorigenesisFibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinomaGenetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapiesSWI/SNF chromatin remodeling complexes and cancerMolecular profiling of biliary tract cancer: a target rich diseaseThe rise of the FGFR inhibitor in advanced biliary cancer: the next cover of time magazine?Cholangiocarcinoma: Current Knowledge and New DevelopmentsDNA Methylation of PITX2 and PANCR Is Prognostic for Overall Survival in Patients with Resected Adenocarcinomas of the Biliary TractLoss of BAP1 Expression Occurs Frequently in Intrahepatic CholangiocarcinomaLoss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytologyHigh-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesotheliomaLatest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapiesComprehensive review of BAP1 tumor predisposition syndrome with report of two new casesBAP1 hereditary cancer predisposition syndrome: a case report and review of literatureGenomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets.Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.What are the precursor and early lesions of peripheral intrahepatic cholangiocarcinoma?Mutations of Chromatin Structure Regulating Genes in Human Malignancies.Therapeutic options for intrahepatic cholangiocarcinomaThe potential role of comprehensive genomic profiling to guide targeted therapy for patients with biliary cancer.2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups.Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic CholangiocarcinomaIdentification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing.Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancerReporting tumor molecular heterogeneity in histopathological diagnosis.The structural basis for cancer treatment decisions.Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5pCRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor.Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.Cholangiocarcinoma: molecular pathways and therapeutic opportunitiesPatterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinomaThe added value of using mutational profiling in addition to cytology in diagnosing aggressive pancreaticobiliary disease: review of clinical cases at a single center.BAP1 missense mutation c.2054 A>T (p.E685V) completely disrupts normal splicing through creation of a novel 5' splice site in a human mesothelioma cell line.Molecular diagnosis of intrahepatic cholangiocarcinoma.
P2860
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P2860
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Exome sequencing identifies fr ...... trahepatic cholangiocarcinomas
@ast
Exome sequencing identifies fr ...... trahepatic cholangiocarcinomas
@en
Exome sequencing identifies fr ...... rahepatic cholangiocarcinomas.
@nl
type
label
Exome sequencing identifies fr ...... trahepatic cholangiocarcinomas
@ast
Exome sequencing identifies fr ...... trahepatic cholangiocarcinomas
@en
Exome sequencing identifies fr ...... rahepatic cholangiocarcinomas.
@nl
prefLabel
Exome sequencing identifies fr ...... trahepatic cholangiocarcinomas
@ast
Exome sequencing identifies fr ...... trahepatic cholangiocarcinomas
@en
Exome sequencing identifies fr ...... rahepatic cholangiocarcinomas.
@nl
P2093
P2860
P50
P356
P1433
P1476
Exome sequencing identifies fr ...... trahepatic cholangiocarcinomas
@en
P2093
Andrea Ruzzenente
Anirban Maitra
David Klimstra
Donald J Lucas
Florin M Selaru
G Johan A Offerhaus
Irinel Popescu
Laura D Wood
Mirte M Streppel
Nickolas Papadopoulos
P2860
P2888
P304
P356
10.1038/NG.2813
P407
P50
P577
2013-11-03T00:00:00Z
P5875
P6179
1049645772