A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.
about
P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disordersRecent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders.Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice.P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Molecular targets and mechanisms for ethanol action in glycine receptorsRegulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsIvermectin antagonizes ethanol inhibition in purinergic P2X4 receptorsStructural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells.Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor.Ethanol is a fast channel inhibitor of P2X4 receptorsImplication of the purinergic system in alcohol use disorders.Activation and regulation of purinergic P2X receptor channelsThe basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol.Ivermectin reduces alcohol intake and preference in mice.Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) RatsAllosteric modulation of ATP-gated P2X receptor channelsA Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder.Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating.Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors.Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder.P2X4: A fast and sensitive purinergic receptor.Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders.Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.
P2860
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P2860
A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A point mutation in the ectodo ...... of ethanol in P2X4 receptors.
@ast
A point mutation in the ectodo ...... of ethanol in P2X4 receptors.
@en
type
label
A point mutation in the ectodo ...... of ethanol in P2X4 receptors.
@ast
A point mutation in the ectodo ...... of ethanol in P2X4 receptors.
@en
prefLabel
A point mutation in the ectodo ...... of ethanol in P2X4 receptors.
@ast
A point mutation in the ectodo ...... of ethanol in P2X4 receptors.
@en
P2093
P2860
P1476
A point mutation in the ectodo ...... of ethanol in P2X4 receptors.
@en
P2093
Liana Asatryan
Maya Popova
Olga Ostrovskaya
Ronald L Alkana
P2860
P304
P356
10.1111/J.1471-4159.2009.06460.X
P407
P577
2009-10-28T00:00:00Z