Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.
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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesAdaptive immunity in the liverProgrammed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapyAssociation of HLA-alleles with the immune regulation of chronic viral infectionsMolecular mechanisms of T cell co-stimulation and co-inhibitionImmune responses to HCV and other hepatitis virusesEmerging concepts in immunity to hepatitis C virus infection.T cell responses in hepatitis C virus infection: historical overview and goals for future researchCD8 T cell persistence in treated HIV infectionThe expression of PD-1 ligands and their involvement in regulation of T cell functions in acute and chronic woodchuck hepatitis virus infectionPhenotypic T cell exhaustion in a murine model of bacterial infection in the setting of pre-existing malignancySpecific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitisInnate and Adaptive Immune Regulation During Chronic Viral InfectionsHepatitis C virus-specific cytotoxic T cell response restoration after treatment-induced hepatitis C virus controlT-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significanceMutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infectionsAge-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected childrenCytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypesHTLV-1 specific CD8+ T cell function augmented by blockade of 2B4/CD48 interaction in HTLV-1 infectionCD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection.Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans.Protective immunity against hepatitis C: many shades of gray.Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.CD127 expression, exhaustion status and antigen specific proliferation predict sustained virologic response to IFN in HCV/HIV co-infected individuals.Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells.Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory moleculesImpaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection.HCV adaptations to altered CD8(+) T-cell immunity during pregnancyT-cell dysfunction and inhibitory receptors in hepatitis C virus infection.Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.Immune control and failure in HCV infection--tipping the balance.Liver immunology.Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa.CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.Negative regulation of hepatitis C virus specific immunity is highly heterogeneous and modulated by pegylated interferon-alpha/ribavirin therapy.Natural Killer Cells in Viral Hepatitis.Control of the inflammatory response mechanisms mediated by natural and induced regulatory T-cells in HCV-, HTLV-1-, and EBV-associated cancers.Will there be a vaccine to prevent HCV infection?Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C.Induction and function of virus-specific CD4+ T cell responses.
P2860
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P2860
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Coexpression of PD-1, 2B4, CD1 ...... on and T cell differentiation.
@ast
Coexpression of PD-1, 2B4, CD1 ...... on and T cell differentiation.
@en
type
label
Coexpression of PD-1, 2B4, CD1 ...... on and T cell differentiation.
@ast
Coexpression of PD-1, 2B4, CD1 ...... on and T cell differentiation.
@en
prefLabel
Coexpression of PD-1, 2B4, CD1 ...... on and T cell differentiation.
@ast
Coexpression of PD-1, 2B4, CD1 ...... on and T cell differentiation.
@en
P2093
P2860
P1433
P1476
Coexpression of PD-1, 2B4, CD1 ...... on and T cell differentiation.
@en
P2093
Bertram Bengsch
Bianca Seigel
Hanspeter Pircher
Hubert E Blum
Marianne Ruhl
Martin Kuntz
Robert Thimme
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000947
P577
2010-06-10T00:00:00Z