Inhibition of nitric oxide synthase as a potential therapeutic target.
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Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthaseDesign and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthaseAngiotensin II induced inflammation in the kidney and in the heart of double transgenic ratsStructural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterinStructural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chainStructural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthaseStructure-Based Design and Synthesis of N ω -Nitro- l -Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural WaterMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsStructure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthasePotent, Highly Selective, and Orally Bioavailable Gem -Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide SynthaseTemperature-Dependent Spin Crossover in Neuronal Nitric Oxide Synthase Bound with the Heme-Coordinating Thioether InhibitorsCyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthaseSimplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase InhibitionThe Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide SynthasesNitric oxide synthases: structure, function and inhibitionNa+ - and Cl- -coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+)Phylogeny drives large scale patterns in Australian marine bioactivity and provides a new chemical ecology rationale for future biodiscoveryA Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric OxideEngineering of complex protein sialylation in plants.Chronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats.The Chemistry of Neurodegeneration: Kinetic Data and Their Implications.Intracellular formation of "undisruptable" dimers of inducible nitric oxide synthase.Detection and localization of two constitutive NOS isoforms in bull spermatozoa.Progressive and concordant expression of PKC-eta and iNOS phenotypes in monocytes from patients with rheumatoid arthritis: association with disease severity.Enhancement of the anti-inflammatory and anti-arthritic effects of theophylline by a low dose of a nitric oxide donor or non-specific nitric oxide synthase inhibitorRegulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors.Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.Tetrahydrobiopterin in cardiovascular health and disease.Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitroAnti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root barkInhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-κB activation in cultured astrocytes and microglial BV-2 cellsDifferential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine in the rat aortaRole of oxidative stress and antioxidants in neurodegenerative diseases.Ubiquitination of inducible nitric oxide synthase is required for its degradation.Anti-inflammatory activity of the ethanol extract of Dictamnus dasycarpus leaf in lipopolysaccharide-activated macrophagesNitric oxide and tissue destruction.Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis.NO as a signalling molecule in the nervous system.Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase
P2860
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P2860
Inhibition of nitric oxide synthase as a potential therapeutic target.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Inhibition of nitric oxide synthase as a potential therapeutic target.
@ast
Inhibition of nitric oxide synthase as a potential therapeutic target.
@en
type
label
Inhibition of nitric oxide synthase as a potential therapeutic target.
@ast
Inhibition of nitric oxide synthase as a potential therapeutic target.
@en
prefLabel
Inhibition of nitric oxide synthase as a potential therapeutic target.
@ast
Inhibition of nitric oxide synthase as a potential therapeutic target.
@en
P2093
P1476
Inhibition of nitric oxide synthase as a potential therapeutic target.
@en
P2093
P304
P356
10.1146/ANNUREV.PHARMTOX.39.1.191
P577
1999-01-01T00:00:00Z