Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform - Wikidata - thesis-toulmin - TriplyDB

Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform

Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform

http://www.wikidata.org/entity/Q33656587

about

Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure Integrative structural modelling of the cardiac thin filament: energetics at the interface and conservation patterns reveal a spotlight on period 2 of tropomyosin The alternative heart: impact of alternative splicing in heart disease.Expression of TPM1κ, a Novel Sarcomeric Isoform of the TPM1 Gene, in Mouse Heart and Skeletal Muscle Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects Investigations into tropomyosin function using mouse models Cardiomyocyte growth and sarcomerogenesis at the intercalated disc.Top-down mass spectrometry of cardiac myofilament proteins in health and disease.Knockout of the Na,K-ATPase α₂-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension.Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein.Expression of tropomyosin in relation to myofibrillogenesis in axolotl hearts.N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy.Tropomyosin dephosphorylation results in compensated cardiac hypertrophy Top-down targeted proteomics for deep sequencing of tropomyosin isoforms.Knockout of the Na,K-ATPase α2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction.Age- and gender-related changes in ventricular performance in wild-type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging: a retrospective study.Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics.Decreasing tropomyosin phosphorylation rescues tropomyosin-induced familial hypertrophic cardiomyopathy Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity.In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry.A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.Polymorphism in tropomyosin structure and function.Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches.Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice.Pre-mRNA mis-splicing of sarcomeric genes in heart failure.Expression of various sarcomeric tropomyosin isoforms in equine striated muscles.Cloning, Sequencing, and the Expression of the Elusive Sarcomeric TPM4α Isoform in Humans.Increased Hemodynamic Load in Early Embryonic Stages Alters Myofibril and Mitochondrial Organization in the Myocardium.Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.Expression of Tropomyosin 1 Gene Isoforms in Human Breast Cancer Cell Lines.Cooperative activation of the cardiac myofilament: the pivotal role of tropomyosin.Expression of a novel tropomyosin isoform in axolotl heart and skeletal muscle.Proteomic Analysis of Endothelin-1 Targets in the Regulation of Cardiomyocyte Proliferation.Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms.Sarcomeric TPM3α in developing chicken.Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish.Tropomyosin isoform expression and phosphorylation in the human heart in health and disease.Exploring the Crosstalk Between and Splicing Machinery Gene Mutations in Dilated Cardiomyopathy

P2860

Q28252609-4C257B71-ED3A-4A9C-B93D-99A6DC3579E0 Q28727222-C170E6E4-F27B-42DC-AD61-ABA70E02248B Q30432053-308602F2-9A2F-477B-9ABA-091C93328E6C Q33607900-42008350-2E20-4E19-B971-96DBDF9B6C10 Q33717809-C15ED66D-1E92-41FD-AD57-857B07517782 Q33854803-093A3898-F8AB-4C00-B7C6-E3C8B346D096 Q34346790-DA1D10E6-567D-4D24-8291-F88805974B58 Q34506950-39DA4CAA-B218-4244-B98F-4386EC85694D Q35395635-A2E469AD-DDE7-4B2D-ABE5-DCB8FCDE1508 Q35396585-22FC5698-BE7C-4C64-8AAF-ED9E3440FBD8 Q35565337-533982B9-F2C5-40D5-9A92-BBE087B16786 Q35604624-AB8B096C-15EF-488B-B5A5-2DD8B32D03DB Q36339491-236DCB2B-DA42-42CE-BDA8-466D9E819946 Q36492849-D92AAC16-8E87-4176-9FAC-F265798EDA13 Q36682535-1B51DF91-E586-40D9-970A-508EA6B16948 Q36764454-E35D15EF-AB13-42E0-B1E7-9DF87A54316D Q36872276-7E72874C-380D-4DD4-81F0-27B32B4C4471 Q37114271-31889DAB-6232-47D1-B6C4-7E0AFC122EFB Q37213860-CE5CF094-3E5D-48B0-B667-876D54BB106E Q37247513-8EEC082A-3AC4-41F9-BDB4-2CA6322E33EC Q37360589-D03263F8-8FCE-4679-A29F-11F2496DA81A Q38108764-9C1CCBB7-B35B-4C4A-8DA7-C6D43FDF2595 Q38119858-18CD880D-625B-45F5-8269-2CD00050BC5D Q38427624-F21628C9-C1D4-40D7-B151-221DEABD1214 Q38853345-77EE8275-2971-4729-BD81-642293DB8D36 Q39003222-B934649E-926D-4422-ABC8-DFE9FEE71FEB Q40956007-E1E4FD2B-FDB3-4CAF-8A7E-7D21B756362B Q41211682-336301E6-E6C3-429C-9AEB-C2FBB50BAF5E Q41600282-1B741FF0-B6DF-4C3E-A30F-2D33E8D20327 Q41901024-88EB095B-07F0-4177-86A3-1FAFE20C86C0 Q42059517-573C76DB-06AC-4276-B0EF-647ADD8BC444 Q42734955-99468C14-9419-4EE2-8DDD-3B1B473C8E29 Q42739976-2EDAC58D-C0D1-4DAF-8E9C-7180E4FE0342 Q46760103-8E97807D-28F3-46FC-B315-985D09BC4FF6 Q49185907-E4EA26C8-06A1-4432-9D46-12E8F5007EB6 Q50000336-EF4C9FE4-D4E4-46C4-8201-8E963491A70B Q50468177-B771A394-1303-4C72-9AF6-EEFBEBC880C6 Q50956362-7E112391-B893-4E3F-9386-EB53F0D51616 Q57646299-8F2223EF-4D7D-4402-9CC4-1C770E602604

P2860

Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform

http://www.wikidata.org/entity/Q33656587

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Molecular and functional chara ...... ific human tropomyosin isoform

@ast

Molecular and functional chara ...... ific human tropomyosin isoform

@en

type

label

Molecular and functional chara ...... ific human tropomyosin isoform

@ast

Molecular and functional chara ...... ific human tropomyosin isoform

@en

prefLabel

Molecular and functional chara ...... ific human tropomyosin isoform

@ast

Molecular and functional chara ...... ific human tropomyosin isoform

@en

P1433

Q33656587-BFFF8545-CFD5-43DA-AEB0-91E0BFC21DAD

P1476

Q33656587-119E5CFE-5A45-4602-81D3-9EF24196CA2D

P2093

Q33656587-12DB8494-C36F-486A-8855-BBF656924372

Q33656587-13A985D8-3B2B-4E60-BA93-2B5A8E283C39

Q33656587-29DC420F-F5FB-45E7-8B6A-EAE1F73E7913

Q33656587-349D015E-BCB6-4099-B00F-1C6B49BEDD9C

Q33656587-35678D51-9AA4-4DE8-B260-26E60E724D4F

Q33656587-49C474F8-BE6B-4E1D-A646-C28421330AAC

Q33656587-6EF812D1-B84B-419E-BA12-E2815E40D782

Q33656587-7CDEB0F9-FF15-4189-A550-B4D7B159CFE6

Q33656587-888B212F-38A4-4479-B065-48B16FE00D90

Q33656587-98986886-3574-46F3-8EFE-2088F39A2486

P2860

Q33656587-031FB43E-8300-402D-B079-1A50441BAF34

Q33656587-0CC0DACD-C26B-4E17-912A-E5A901A66332

Q33656587-1852F526-EE89-4D74-8762-E7544A36A5A5

Q33656587-1EB709DA-C644-4E06-92DF-F1AF55488BAE

Q33656587-23A329C2-887F-4829-963D-272BA6D486D9

Q33656587-2C2E2949-17C1-464F-9873-A0778E4AB0D8

Q33656587-3AFEEA20-C713-4300-B1FD-B8A3599E3589

Q33656587-3C1EEA4D-67F1-40DE-83AE-D402F2680699

Q33656587-3C790118-985F-407E-9F5C-C69AC19ED271

Q33656587-51799CA7-B3F4-450B-A55F-54643D3A00A1

P304

Q33656587-165E440A-7F86-44AA-A655-020E0A83A9CA

P31

Q33656587-87A0E53B-9535-4BA8-9364-699A722F511B

P356

Q33656587-06CAE291-F218-4FE9-A0B2-33F731EBA257

P407

Q33656587-C6E860BC-4E28-4E0A-A427-1147B558ECBE

P433

Q33656587-507647C3-49C0-458E-A977-C6BFB690C148

P478

Q33656587-8ABA5A8F-2043-4420-BCE3-5AF59FEAB05B

P50

Q33656587-9FC5A7D9-DED9-4985-97AE-257E6C09CCC2

P577

Q33656587-3D689D57-8871-49A1-BAA4-B56587AF3FEC

P698

Q33656587-9532B8DF-9E88-4AE7-B22C-D64F5ED2D983

P932

Q33656587-756DB93B-A2C2-4B15-9CB8-E0C8CA1CE48F

P356

CIRCULATIONAHA.109.889725

P1433

P1476

Molecular and functional chara ...... ific human tropomyosin isoform

@en

P2093

Arnold Schwartz

http://www.w3.org/2001/XMLSchema#string

Beata M Wolska

http://www.w3.org/2001/XMLSchema#string

Chehade N Karam

http://www.w3.org/2001/XMLSchema#string

Christian F Bulcao

http://www.w3.org/2001/XMLSchema#string

David F Wieczorek

http://www.w3.org/2001/XMLSchema#string

Dipak K Dube

http://www.w3.org/2001/XMLSchema#string

Ganapathy Jagatheesan

http://www.w3.org/2001/XMLSchema#string

Greg P Boivin

http://www.w3.org/2001/XMLSchema#string

Ilona Bodi

http://www.w3.org/2001/XMLSchema#string

Karen M D'Souza

http://www.w3.org/2001/XMLSchema#string

P2860

Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity

Deciphering the design of the tropomyosin molecule

Functional analysis of human cardiac troponin by the in vitro motility assay: comparison of adult, foetal and failing hearts

Myosin heavy chain isoform expression in the failing and nonfailing human heart

Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

The molecular basis for tropomyosin isoform diversity

Molecular and physiological effects of overexpressing striated muscle beta-tropomyosin in the adult murine heart

Molecular diversity of myofibrillar proteins: gene regulation and functional significance

Thick filament proteins and performance in human heart failure

Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure

P304

410-418

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1161/CIRCULATIONAHA.109.889725

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

121

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-01-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20065163

http://www.w3.org/2001/XMLSchema#string

P932

2822663

http://www.w3.org/2001/XMLSchema#string