about
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signallingRegulation of TOR by small GTPasesCancer of the Pancreas: Molecular Pathways and Current Advancement in TreatmentKRAS Mutant Pancreatic Cancer: No Lone Path to an Effective TreatmentApproaches of targeting Rho GTPases in cancer drug discoveryProtein prenylation and synaptic plasticity: implications for Alzheimer's diseaseSmall G proteins in the cardiovascular system: physiological and pathological aspectsP53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.Intracellular oxygen determined by respiration regulates localization of Ras and prenylated proteins.RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast CancerMetalloprotein–Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal–Ligand Interactions in a Metalloprotein Active SitePancreatic cancer, treatment options, and GI-4000Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeuticsPrenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoformCellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated ProteinsChemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasisGlobal proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogueTargeting protein lipidation in diseaseExpansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochoresDrug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.Niche-based screening identifies small-molecule inhibitors of leukemia stem cellsTipifarnib prevents development of hypoxia-induced pulmonary hypertension.Comprehensive pharmacological profiling of neurofibromatosis cell lines.In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and CandidaManumycin induces apoptosis in prostate cancer cellsThe KLK5 protease suppresses breast cancer by repressing the mevalonate pathwayA combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins.Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer.Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms.Engineering protein farnesyltransferase for enzymatic protein labeling applications.An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.Oncogenic KRAS signalling in pancreatic cancer.Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation.Development of synthetic lethality anticancer therapeutics.Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy.Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer.MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1.Protein prenylation: enzymes, therapeutics, and biotechnology applications.Global profiling of protein lipidation using chemical proteomic technologies
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Targeting protein prenylation for cancer therapy
@ast
Targeting protein prenylation for cancer therapy
@en
type
label
Targeting protein prenylation for cancer therapy
@ast
Targeting protein prenylation for cancer therapy
@en
prefLabel
Targeting protein prenylation for cancer therapy
@ast
Targeting protein prenylation for cancer therapy
@en
P2093
P2860
P356
P1476
Targeting protein prenylation for cancer therapy
@en
P2093
Andrew D Hamilton
Norbert Berndt
Saïd M Sebti
P2860
P2888
P304
P356
10.1038/NRC3151
P407
P577
2011-10-24T00:00:00Z
P6179
1027538896