Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.
about
Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegansIdentification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibitionHuntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review seriesSpatial protein quality control and the evolution of lineage-specific ageingAging as an event of proteostasis collapseCollapse of proteostasis represents an early molecular event in Caenorhabditis elegans agingUbiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathwaysConnecting the dots in Huntington's disease with protein interaction networksModel systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityUBA1: At the Crossroads of Ubiquitin Homeostasis and NeurodegenerationRegulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genesIntegrated control of protein degradation in C. elegans muscleTherapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseAutomated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans modelsGraded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome PathwayGlobal functional analyses of cellular responses to pore-forming toxinsDestabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicityAn ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegansGenome-wide screen for modifiers of ataxin-3 neurodegeneration in DrosophilaNeuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock responseIdentification of a tissue-selective heat shock response regulatory networkWidespread protein aggregation as an inherent part of aging in C. elegansNovel polyglutamine model uncouples proteotoxicity from agingA genetic screening strategy identifies novel regulators of the proteostasis networkSpecific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activityDeficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin DeficiencyMechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.The struggle by Caenorhabditis elegans to maintain proteostasis during aging and diseaseA chaperome subnetwork safeguards proteostasis in aging and neurodegenerative diseaseC. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during agingCharacterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegansA genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug targetLarge-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model.HSF1 protects neurons through a novel trimerization- and HSP-independent mechanismProteotoxic stress and inducible chaperone networks in neurodegenerative disease and agingStress and aging induce distinct polyQ protein aggregation statesDynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo.Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects
P2860
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P2860
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Genome-wide RNA interference s ...... of polyglutamine aggregation.
@ast
Genome-wide RNA interference s ...... of polyglutamine aggregation.
@en
type
label
Genome-wide RNA interference s ...... of polyglutamine aggregation.
@ast
Genome-wide RNA interference s ...... of polyglutamine aggregation.
@en
prefLabel
Genome-wide RNA interference s ...... of polyglutamine aggregation.
@ast
Genome-wide RNA interference s ...... of polyglutamine aggregation.
@en
P2093
P2860
P356
P1476
Genome-wide RNA interference s ...... of polyglutamine aggregation.
@en
P2093
Alejandro Chavez
Ellen A A Nollen
Richard I Morimoto
Ronald H A Plasterk
Soojin Kim
Susana M Garcia
P2860
P304
P356
10.1073/PNAS.0307697101
P407
P577
2004-04-14T00:00:00Z