about
Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathyImmunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.Synergistic interactions between repeats in tau protein and Aβ amyloids may be responsible for accelerated aggregation via polymorphic states.Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.Understanding the kinetic roles of the inducer heparin and of rod-like protofibrils during amyloid fibril formation by Tau proteinCross-seeding and conformational selection between three- and four-repeat human Tau proteins.Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations.Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicityConformational features of tau fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant protein.Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Characterization of tau fibrillization in vitro.
@ast
Characterization of tau fibrillization in vitro.
@en
type
label
Characterization of tau fibrillization in vitro.
@ast
Characterization of tau fibrillization in vitro.
@en
prefLabel
Characterization of tau fibrillization in vitro.
@ast
Characterization of tau fibrillization in vitro.
@en
P2093
P2860
P1476
Characterization of tau fibrillization in vitro.
@en
P2093
Kurt R Brunden
Shaohua Xu
Virginia M-Y Lee
P2860
P304
P356
10.1016/J.JALZ.2009.06.002
P577
2010-03-01T00:00:00Z