Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling. - Wikidata - thesis-toulmin - TriplyDB

Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.

Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.

http://www.wikidata.org/entity/Q33810050

about

Altered expression of stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in cancer: will they become a new battlefield for oncotherapy?The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma Multiple functions of BCL-2 family proteins.Remodeling the proteostasis network to rescue glucocerebrosidase variants by inhibiting ER-associated degradation and enhancing ER folding.Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis.Signaling cell death from the endoplasmic reticulum stress response Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease WT1/EGR1-mediated control of STIM1 expression and function in cancer cells The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival.Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosis resistance and Ca2+ homeostasis Mitochondrial Ca(2+) signals in autophagy.Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability.Human Sulfatase-1 Improves the Effectiveness of Cytosine Deaminase Suicide Gene Therapy with 5-Fluorocytosine Treatment on Hepatocellular Carcinoma Cell Line HepG2 In Vitro and In Vivo.An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.Regulation of the autophagic bcl-2/beclin 1 interaction.The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.Apoptosis and autophagy: decoding calcium signals that mediate life or death.IP(3) Receptors, Mitochondria, and Ca Signaling: Implications for Aging Inositol 1,4,5-trisphosphate receptor subtype-specific regulation of calcium oscillations.Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease.Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival.Mitochondrial Ca(2+) and apoptosis.The secrets of the Bcl-2 family.The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond.MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia.Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.The Bcl-2 homolog Nrz inhibits binding of IP3 to its receptor to control calcium signaling during zebrafish epiboly.Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis.Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs.Non-apoptotic functions of BCL-2 family proteins.Bcl-2 proteins and calcium signaling: complexity beneath the surface.Impact of intracellular ion channels on cancer development and progression.

P2860

Q26751353-6574336B-7CDD-492F-BE69-5E6C4B28EB0F Q28115007-C656099B-E5BF-44EA-A175-703300319311 Q28397854-B96DF706-4438-4C1F-BEF6-1B11B3002E2E Q28476828-EDC06CF9-336A-47D4-8879-08326AF03916 Q34326024-A34D3C95-1D5A-481F-A80B-766F067F9A0E Q34688803-82D299AB-EEDB-4A0A-8D58-86F22406643C Q34707190-69FADDD2-E229-4507-AEBF-779548E74560 Q34785870-F384C339-C6FE-4BBB-96FF-A24F1A318A4B Q34803666-ED009762-FBAC-48F5-8475-1B8BFE21ADAB Q35020243-9D4F456A-B0C7-4A59-972B-6A47351E1DC4 Q35122788-6C427F34-6090-442B-9372-A375058ABC40 Q35575649-29C4233E-6C98-4ED4-BCFF-0D48975B20D0 Q35580876-51A45396-55A3-4CCF-9D6A-120E32CF8C74 Q35687120-A0C4C14C-0624-4576-A130-9A3A2D086BC6 Q35928205-E4DBC7B2-CB16-45E7-8757-FC129C4A9C18 Q36066657-48C4433E-7AB9-4BF8-8767-6A5C194CDEE4 Q36074837-486769CB-A8D2-4C0C-BC11-E692BBCA250D Q36412965-D5C850F0-6638-41E7-9617-285F0208BA36 Q36602853-012FB353-222F-4D74-943B-C88851B52459 Q36770769-7B9B9ED4-CD01-4B6E-BA36-30496ACA21ED Q36794502-001D5A14-AAD2-480B-BFCB-BE9FB9038874 Q37000616-796707EA-CEDD-42BB-AB80-E651D57C7C9C Q37512209-6CDD320C-B4F1-4DC9-81CC-E8C99655028D Q37688303-72F9ECF6-E0E1-49F5-8EDB-975B00AC0D7B Q37786444-1572AFC9-E9DD-4F64-A165-CC8F119361B9 Q37855570-872CE286-558B-4A4F-8414-9493AD008693 Q37863569-06F3CC6B-17E4-478D-9ABB-B07EDDA4E7E5 Q37882819-F262D4A0-2C47-4905-9D88-C17D67C51462 Q37959319-B44FA48C-8ACC-43E6-8043-9CE2D46B9F3E Q38000429-F8161D9B-785E-4F16-9005-2C94437520C7 Q38039293-F2F83EC5-B96D-48D2-AD2B-FBC4AD959824 Q38041423-24C309D6-8986-4755-ACE6-F699F15145DB Q38174356-0489C9DB-47F8-4F76-B095-5E2E5F352FA2 Q38197005-E1E4A9E8-E61D-4DBC-B21C-69A194537D09 Q38308967-515D82C7-7C8B-4BC4-BA44-C5EBBEC4544E Q38455911-C8A34F23-EDC4-4AFD-86A6-45040EF3D2C9 Q38718031-62E2D8C0-5B16-4006-B43E-0DB0DC19D3D4 Q38753660-4CF92282-C811-4A63-AC6D-F42823FC6C24 Q38773462-6241C927-F018-4CFD-A364-DBEA0CFC6AF1 Q38862322-C4150EC9-5230-45F1-B267-692D01927D68

P2860

Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.

http://www.wikidata.org/entity/Q33810050

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Apoptosis protection by Mcl-1 ...... ptor-dependent Ca2+ signaling.

@ast

Apoptosis protection by Mcl-1 ...... ptor-dependent Ca2+ signaling.

@en

type

label

Apoptosis protection by Mcl-1 ...... ptor-dependent Ca2+ signaling.

@ast

Apoptosis protection by Mcl-1 ...... ptor-dependent Ca2+ signaling.

@en

prefLabel

Apoptosis protection by Mcl-1 ...... ptor-dependent Ca2+ signaling.

@ast

Apoptosis protection by Mcl-1 ...... ptor-dependent Ca2+ signaling.

@en

P1433

Q33810050-4942C1CF-4FA5-49ED-BD39-C68EB65BA6D6

P1476

Q33810050-2EA99D1E-10FA-4FD9-84AC-87F6E149C716

P2093

Q33810050-28113182-8BCF-43A6-AE0F-B1D55CE6E8BC

Q33810050-74EDD625-DA08-44E4-9846-7A118D87E013

Q33810050-7776F356-F264-4F81-9053-20A2AC50CADE

Q33810050-BD38E187-A94E-494A-9A31-4EEDC89E0DBC

Q33810050-EA17FEA3-123E-4D0A-A363-4440AF6F546D

P2860

Q33810050-0438418A-30F0-45CD-89AB-1FFE9C669E0B

Q33810050-06CEE0A0-DF30-486C-B6F0-56C301C3FC48

Q33810050-159E1069-EA20-45BB-895F-0947572A846D

Q33810050-1B618FF5-EAA1-4363-9D36-29C12677827A

Q33810050-34C8D5C5-F1CA-4212-85C2-567ED780E3EF

Q33810050-36C0D032-100C-43CD-A410-C83907D1E343

Q33810050-3A39D397-6740-4848-A692-1ABBF6192585

Q33810050-3B7D857C-9A3C-4F8B-85F2-E1A59688F1C1

Q33810050-3BB05ACF-051E-41DD-A630-66A8266D25D2

Q33810050-446568A4-1409-4155-A2C0-2EB6A0A4DDD0

P304

Q33810050-A027DB01-B6FD-4F4E-AA18-8571B7979CF8

P31

Q33810050-71A82259-F4F5-4723-A84C-45F32DD4C6CD

P356

Q33810050-2C0354DB-D7A8-49A6-92F1-AFA136147EC6

P407

Q33810050-32B754DD-CAB8-4128-A209-D60D592F844F

P433

Q33810050-7CBC5369-000F-43AE-ACC9-4E6D9244AA8E

P478

Q33810050-6DCAF8D8-EC56-4F5D-86ED-C3DABC59E7E0

P577

Q33810050-6AE4C17F-E89E-4765-B0C1-53521A3FAA9D

P698

Q33810050-7E98F609-E89A-42D0-9105-600F5DAE3619

P932

Q33810050-1B68D459-2BC4-4035-85E9-8CD2ACEBDFB9

P356

JBC.M109.096040

P1433

Journal of Biological Chemistry

P1476

Apoptosis protection by Mcl-1 ...... ptor-dependent Ca2+ signaling.

@en

P2093

Carl White

http://www.w3.org/2001/XMLSchema#string

Emily F Eckenrode

http://www.w3.org/2001/XMLSchema#string

Gopal V Velmurugan

http://www.w3.org/2001/XMLSchema#string

J Kevin Foskett

http://www.w3.org/2001/XMLSchema#string

Jun Yang

http://www.w3.org/2001/XMLSchema#string

P2860

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

Inositol trisphosphate receptor Ca2+ release channels.

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

Bcl-2 and calcium: controversy beneath the surface.

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum.

P304

13678-13684

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M109.096040

http://www.w3.org/2001/XMLSchema#string

P407

P433

18

http://www.w3.org/2001/XMLSchema#string

P478

285

http://www.w3.org/2001/XMLSchema#string

P577

2010-02-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20189983

http://www.w3.org/2001/XMLSchema#string

P932

2859530

http://www.w3.org/2001/XMLSchema#string