An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. - Wikidata - thesis-toulmin - TriplyDB

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.

http://www.wikidata.org/entity/Q33843109

about

Development of anticancer agents targeting the Wnt/β-catenin signaling Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies Wnt signalling in smooth muscle cells and its role in cardiovascular disorders Key Fibrogenic Signaling Cancer stem cells in colorectal cancer from pathogenesis to therapy: controversies and perspectives Inhibition of oncogenic Wnt signaling through direct targeting of -catenin Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials Wnt/β-catenin signalling in prostate cancer Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting E-cadherin-downregulation and RECK-upregulation are coupled in the non-malignant epithelial cell line MCF10A but not in multiple carcinoma-derived cell lines.Actomyosin contractility provokes contact inhibition in E-cadherin-ligated keratinocytes.Winning WNT: race to Wnt signaling inhibitors.Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt.RNAi screening: new approaches, understandings, and organisms.Synthetic, non-saccharide, glycosaminoglycan mimetics selectively target colon cancer stem cells.Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).Crosstalk between nuclear MET and SOX9/β-catenin correlates with castration-resistant prostate cancer Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells.Inhibitors of endocytosis prevent Wnt/Wingless signalling by reducing the level of basal β-catenin/Armadillo Tackling the cancer stem cells - what challenges do they pose?Small molecule modulators of Wnt/β-catenin signaling.In vitro effects of a small-molecule antagonist of the Tcf/ß-catenin complex on endometrial and endometriotic cells of patients with endometriosis.Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells.Inhibition of androgen receptor and β-catenin activity in prostate cancer LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma.FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma.Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish.Can we safely target the WNT pathway?Divergent Androgen Receptor and Beta-Catenin Signaling in Prostate Cancer Cells.Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics Inhibition of β-catenin-TCF1 interaction delays differentiation of mouse embryonic stem cells.High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer.Dishevelled limits Notch signalling through inhibition of CSL

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An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.

http://www.wikidata.org/entity/Q33843109

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

An RNAi-based chemical genetic ...... nt/wingless signaling pathway.

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An RNAi-based chemical genetic ...... nt/wingless signaling pathway.

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An RNAi-based chemical genetic ...... nt/wingless signaling pathway.

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PNAS.1017496108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

An RNAi-based chemical genetic ...... nt/wingless signaling pathway.

@en

P2093

Anthony M C Brown

http://www.w3.org/2001/XMLSchema#string

Brittany B Carson

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Foster C Gonsalves

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Keren Klein

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Laura A Ekas

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Ramanuj DasGupta

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Robert Nagourney

http://www.w3.org/2001/XMLSchema#string

Shauna Katz

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Steve Evans

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Timothy Cardozo

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P2860

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.

WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene

Beta-catenin: a transforming actor on many stages

Crystal structure of a beta-catenin/Tcf complex

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin

Wnt signaling and cancer

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5954-5963

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10.1073/PNAS.1017496108

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108

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21393571

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