A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptor
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesExploring the ATP-binding site of P2X receptorsSize matters in activation/inhibition of ligand-gated ion channelsPrinciples and properties of ion flow in P2X receptorsTightening of the ATP-binding sites induces the opening of P2X receptor channelsAminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes.Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptorAgonist trapped in ATP-binding sites of the P2X2 receptor.Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsAgonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels.Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channelA Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 ReceptorsOptical control of an ion channel gateStructural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating.Heteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.On the permeation of large organic cations through the pore of ATP-gated P2X receptors.P2X Receptor Activation.Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gatingConformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.P2X2 Dominant Deafness Mutations Have No Negative Effect on Wild-Type Isoform: Implications for Functional Rescue and in Deafness Mechanism.The Dynamic Behavior of the P2X4 Ion Channel in the Closed Conformation.
P2860
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P2860
A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptor
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A putative extracellular salt ...... of the ATP-gated P2X2 receptor
@ast
A putative extracellular salt ...... of the ATP-gated P2X2 receptor
@en
type
label
A putative extracellular salt ...... of the ATP-gated P2X2 receptor
@ast
A putative extracellular salt ...... of the ATP-gated P2X2 receptor
@en
prefLabel
A putative extracellular salt ...... of the ATP-gated P2X2 receptor
@ast
A putative extracellular salt ...... of the ATP-gated P2X2 receptor
@en
P2093
P2860
P356
P1476
A putative extracellular salt ...... of the ATP-gated P2X2 receptor
@en
P2093
Adeline Martz
Antoine Taly
Lia Prado de Carvalho
Ruotian Jiang
Sophie Gonin
Thomas Grutter
P2860
P304
15805-15815
P356
10.1074/JBC.M110.101980
P407
P577
2010-03-22T00:00:00Z