Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.

Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.

Item
http://www.wikidata.org/entity/Q33871220
RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.The RAG2 C terminus suppresses genomic instability and lymphomagenesis.Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Generation of Gross Chromosomal Rearrangements by a Single Engineered DNA Double Strand Break.How does DNA break during chromosomal translocations?Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.Mechanisms of oncogenic chromosomal translocations.A Novel Quantitative Fluorescent Reporter Assay for RAG Targets and RAG Activity.PREVENTING THE CHROMOSOMAL TRANSLOCATIONS THAT CAUSE CANCERRAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaksStructural genomic changes during mammalian ontogeny: a new dimension.
P2860

Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.

Item
http://www.wikidata.org/entity/Q33871220
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Non-consensus heptamer sequenc ...... ternative DNA repair pathways.
@ast
Non-consensus heptamer sequenc ...... ternative DNA repair pathways.
@en
type
label
Non-consensus heptamer sequenc ...... ternative DNA repair pathways.
@ast
Non-consensus heptamer sequenc ...... ternative DNA repair pathways.
@en
prefLabel
Non-consensus heptamer sequenc ...... ternative DNA repair pathways.
@ast
Non-consensus heptamer sequenc ...... ternative DNA repair pathways.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Non-consensus heptamer sequenc ...... ternative DNA repair pathways.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932