Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer
about
RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathwayCCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis.Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repairGenetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.Statistical association of basal cell keratins with metastasis-inducing proteins in a prognostically unfavorable group of sporadic breast cancers.S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer.FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents.Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.Metastasis-inducing proteins are widely expressed in human brain metastases and associated with intracranial progression and radiation responseTowards a molecular understanding of the fanconi anemia core complexSeveral tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance.
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P2860
Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer
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2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Significance of the Fanconi an ...... metastatic human breast cancer
@ast
Significance of the Fanconi an ...... metastatic human breast cancer
@en
type
label
Significance of the Fanconi an ...... metastatic human breast cancer
@ast
Significance of the Fanconi an ...... metastatic human breast cancer
@en
prefLabel
Significance of the Fanconi an ...... metastatic human breast cancer
@ast
Significance of the Fanconi an ...... metastatic human breast cancer
@en
P2093
P2860
P1476
Significance of the Fanconi an ...... metastatic human breast cancer
@en
P2093
Abdulaziz Aladwani
Angela M Platt-Higgins
Christopher R West
Dong L Barraclough
James B Wilson
John H R Winstanley
Lowri M Davies
Nigel J Jones
Philip S Rudland
Roger Barraclough
P2860
P304
P356
10.2353/AJPATH.2010.090779
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P577
2010-04-02T00:00:00Z