A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).
about
The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progressionFunctional ablation of pRb activates Cdk2 and causes antiestrogen resistance in human breast cancer cellsSuppression of E1A-mediated transformation by the p50E4F transcription factorA cancer-specific transcriptional signature in human neoplasia.Paradigms of growth control: relation to Cdk activation.Biology of human papillomaviruses.Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteinsInhibition of S-phase progression by adeno-associated virus Rep78 protein is mediated by hypophosphorylated pRbDensity-dependent growth inhibition of fibroblasts ectopically expressing p27(kip1)New insights into the tumor suppression function of P27(kip1)Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cellsCdk inhibitory nucleoside analogs prevent transcription from viral genomes.Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entryLoss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis.Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1aToll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts.E2F activates late-G1 events but cannot replace E1A in inducing S phase in terminally differentiated skeletal muscle cells.Cyclin E and cyclin A are likely targets of Src for PDGF-induced DNA synthesis in fibroblasts.Cell transformation by the E5/E8 protein of bovine papillomavirus type 4. p27(Kip1), Elevated through increased protein synthesis is sequestered by cyclin D1-CDK4 complexes.Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway.Hypoxia inhibits mesenchymal stem cell proliferation through HIF1α-dependent regulation of P27.Recruitment of TRRAP required for oncogenic transformation by E1A.
P2860
Q28565179-E608AB64-B09D-458A-A339-FB35753C48C3Q33308716-A811DDD1-ED98-4BF5-A60D-AB004366D8E2Q33958530-789AAFA7-62E6-4759-8E01-AA59943A0A6AQ34078670-0E296C99-D002-4452-BCEC-9D0B461ADB98Q34130676-BD75C189-D0C8-4F92-A574-F2FE88476AC8Q34291548-BEEB3BB8-7D22-4DCD-A617-D9B440868883Q34343774-F4D075D2-0746-4191-A82A-C1363BAB9277Q34486909-5F575F50-DFC6-44EC-B1F2-0F123383BA2DQ34726762-8B89A608-F642-41D1-A46E-14499B6D4A6BQ36084916-C9A73D1B-1AD2-4536-BB62-68CDCA3D7882Q36246072-C6A922D7-9D18-4A59-8A66-BF75C66B20B4Q36296415-839D8CFB-0E8B-4B70-904B-F7ABD2E7A6F9Q36325712-E4CAD8A8-A1F9-4D5B-9391-4F55EA0A7C19Q39647656-3EA6CC21-593A-4924-AE17-FA47917EBF45Q40407703-60D343FC-29F3-4600-9A3A-23F18BB839FFQ40443156-422FCAA1-3248-47ED-9F09-9AAE39F5C581Q40928313-617F6436-D340-4118-97A3-3C4082C3408FQ42810897-5E8FDD9C-A581-4D5C-BCA8-1C7EA800BE95Q42827251-EC59C2C6-F42A-4004-8F56-EEF92157A5ABQ45884349-E823F302-DFBD-441B-A936-EDC9D5031995Q51543945-8E0B846C-1A88-4D93-8653-AD1CE58FA922Q52544957-2336B267-9EDD-406A-B568-C7AD2F1FD02E
P2860
A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A novel function of adenovirus ...... the CDK2 inhibitor p27(Kip1).
@ast
A novel function of adenovirus ...... the CDK2 inhibitor p27(Kip1).
@en
type
label
A novel function of adenovirus ...... the CDK2 inhibitor p27(Kip1).
@ast
A novel function of adenovirus ...... the CDK2 inhibitor p27(Kip1).
@en
prefLabel
A novel function of adenovirus ...... the CDK2 inhibitor p27(Kip1).
@ast
A novel function of adenovirus ...... the CDK2 inhibitor p27(Kip1).
@en
P2093
P2860
P356
P1433
P1476
A novel function of adenovirus ...... y the CDK2 inhibitor p27(Kip1)
@en
P2093
Alevizopoulos K
P2860
P304
P356
10.1093/EMBOJ/17.20.5987
P407
P50
P577
1998-10-01T00:00:00Z