Regulation of insulin secretion: role of mitochondrial signalling. - Wikidata - thesis-toulmin - TriplyDB

Regulation of insulin secretion: role of mitochondrial signalling.

Regulation of insulin secretion: role of mitochondrial signalling.

http://www.wikidata.org/entity/Q33914248

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β-Cell glutamate signaling: Its role in incretin-induced insulin secretion Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploring Redox homeostasis in pancreatic β cells A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells Calcium release channel RyR2 regulates insulin release and glucose homeostasis DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals.Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion Increased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretion NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells.Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.Increased density of inhibitory noradrenergic parenchymal nerve fibers in hypertrophic islets of Langerhans of obese mice.Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.Comparative Analysis of the Mitochondrial Physiology of Pancreatic β Cells Targeting mitochondrial alterations to prevent type 2 diabetes--evidence from studies of dietary redox-active compounds.Cardiac anaplerosis in health and disease: food for thought.Whole genome SNP genotyping and exome sequencing reveal novel genetic variants and putative causative genes in congenital hyperinsulinism.Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells.Profiling hepatic microRNAs in zebrafish: fluoxetine exposure mimics a fasting response that targets AMP-activated protein kinase (AMPK)L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2 Advanced glycation end products and oxidative stress in type 2 diabetes mellitus.Activation and inhibition of pyruvate carboxylase from Rhizobium etli.Novel insights into the biotin carboxylase domain reactions of pyruvate carboxylase from Rhizobium etli.Characterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation.Mechanisms of glucose sensing in the pancreatic β-cell: A computational systems-based analysis.Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells.The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion.How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.Cytokine-mediated β-cell damage in PARP-1-deficient islets.NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells.Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.Cryopreservation effects on intermediary metabolism in a pancreatic substitute: a (13)C nuclear magnetic resonance study.Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs.

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Regulation of insulin secretion: role of mitochondrial signalling.

http://www.wikidata.org/entity/Q33914248

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Regulation of insulin secretion: role of mitochondrial signalling.

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Regulation of insulin secretion: role of mitochondrial signalling.

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type

label

Regulation of insulin secretion: role of mitochondrial signalling.

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Regulation of insulin secretion: role of mitochondrial signalling.

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prefLabel

Regulation of insulin secretion: role of mitochondrial signalling.

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Regulation of insulin secretion: role of mitochondrial signalling.

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Regulation of insulin secretion: role of mitochondrial signalling.

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A Wutthisathapornchai

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J C Wallace

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M J MacDonald

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S Jitrapakdee

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P2860

NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism

Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase

A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells

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