Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.
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Spines, plasticity, and cognition in Alzheimer's model miceMechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's diseaseSynaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice.Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling β-amyloid production.Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD micePERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.In vivo characterization of a bigenic fluorescent mouse model of Alzheimer's disease with neurodegenerationMolecular Differences and Similarities Between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis.Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease.Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse modelsTemporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease.Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP levelArea-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus.Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer's diseaseRNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation.A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice.Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice.Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stagesAn update of animal models of Alzheimer disease with a reevaluation of plaque depositions.Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's diseaseMechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease.Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β.EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease.Ginsenoside Rg1 decreases neurofibrillary tangles accumulation in retina by regulating activities of neprilysin and PKA in retinal cells of AD mice model.MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer's Disease.BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathwayEnvironmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model
P2860
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P2860
Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Genetic reductions of beta-sit ...... lzheimer's disease model mice.
@ast
Genetic reductions of beta-sit ...... lzheimer's disease model mice.
@en
type
label
Genetic reductions of beta-sit ...... lzheimer's disease model mice.
@ast
Genetic reductions of beta-sit ...... lzheimer's disease model mice.
@en
prefLabel
Genetic reductions of beta-sit ...... lzheimer's disease model mice.
@ast
Genetic reductions of beta-sit ...... lzheimer's disease model mice.
@en
P2860
P1476
Genetic reductions of beta-sit ...... lzheimer's disease model mice.
@en
P2093
Latha Devi
Masuo Ohno
P2860
P304
P356
10.1111/J.1460-9568.2009.07031.X
P407
P577
2009-12-21T00:00:00Z