Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.
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Serum and Glucocorticoid Regulated Kinase 1 in Sodium HomeostasisTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesEpigenetics of epithelial Na(+) channel-dependent sodium uptake and blood pressure regulationRegulation of αENaC transcriptionEpigenetics and the control of the collecting duct epithelial sodium channelA medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.AF17 facilitates Dot1a nuclear export and upregulates ENaC-mediated Na+ transport in renal collecting duct cells.Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic ratsAqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferationENaCs and ASICs as therapeutic targets.Aqp2-expressing cells give rise to renal intercalated cells.An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC geneSp1 trans-activates and is required for maximal aldosterone induction of the αENaC gene in collecting duct cells.Aldosterone reprograms promoter methylation to regulate αENaC transcription in the collecting duct.Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.Physical and functional interaction of Rnf2 with Af9 regulates basal and aldosterone-stimulated transcription of the α-ENaC gene in a renal collecting duct cell line.Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreATherapeutic potential of serum and glucocorticoid inducible kinase inhibition.The upstreams and downstreams of H3K79 methylation by DOT1L.Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice.
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P2860
Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.
description
2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
Dot1a contains three nuclear l ...... nel (ENaC) at multiple levels.
@ast
Dot1a contains three nuclear l ...... nel (ENaC) at multiple levels.
@en
type
label
Dot1a contains three nuclear l ...... nel (ENaC) at multiple levels.
@ast
Dot1a contains three nuclear l ...... nel (ENaC) at multiple levels.
@en
prefLabel
Dot1a contains three nuclear l ...... nel (ENaC) at multiple levels.
@ast
Dot1a contains three nuclear l ...... nel (ENaC) at multiple levels.
@en
P2093
P2860
P921
P1476
Dot1a contains three nuclear l ...... nel (ENaC) at multiple levels.
@en
P2093
Mary Rose Reisenauer
Steven W Wang
Wenzheng Zhang
P2860
P304
P356
10.1152/AJPRENAL.00105.2010
P577
2010-04-28T00:00:00Z