Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.
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Antiviral perspectives for chikungunya virusMutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2Early Events in Chikungunya Virus Infection-From Virus Cell Binding to Membrane FusionExposure of epitope residues on the outer face of the chikungunya virus envelope trimer determines antibody neutralizing efficacyPrime-boost immunization strategies against Chikungunya virusAlphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral ResponsesThe Global Virus Network: Challenging chikungunyaChikungunya virus (CHIKV) inhibitors from natural sources: a medicinal chemistry perspectiveMechanism and role of MCP-1 upregulation upon chikungunya virus infection in human peripheral blood mononuclear cellsViperin restricts chikungunya virus replication and pathology.Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor librarysiRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus InfectionAntiviral effect of compounds derived from the seeds of Mammea americana and Tabernaemontana cymosa on Dengue and Chikungunya virus infectionsThe citrus flavanone naringenin impairs dengue virus replication in human cellsMutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine DesignStress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses.Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensisScreening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses.Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice.A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizationsSilibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking.Characterization of synthetic Chikungunya viruses based on the consensus sequence of recent E1-226V isolatesLoss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody responseUnique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development.Antiviral activity of silymarin against chikungunya virusKinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay.Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis.Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein.Detection of Persistent Chikungunya Virus RNA but not Infectious Virus in Experimental Vertical Transmission in Aedes aegypti from Malaysia.An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling.Approaches to the treatment of disease induced by chikungunya virus.A novel poxvirus-based vaccine, MVA-CHIKV, is highly immunogenic and protects mice against chikungunya infection.Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking.Flavonoids: promising natural compounds against viral infections.Potential entry inhibitors of the envelope protein (E2) of Chikungunya virus: in silico structural modeling, docking and molecular dynamic studies.Design and Validation of Novel Chikungunya Virus Protease Inhibitors.
P2860
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P2860
Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@ast
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@en
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@nl
type
label
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@ast
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@en
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@nl
prefLabel
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@ast
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@en
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@nl
P2860
P50
P1433
P1476
Inhibitors of alphavirus entry ...... l line and virus-based assays.
@en
P2093
Leena Pohjala
Margus Varjak
P2860
P304
P356
10.1371/JOURNAL.PONE.0028923
P407
P5008
P577
2011-12-19T00:00:00Z