Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation
about
Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22RDissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domainCloning of a type I cytokine receptor most related to the IL-2 receptor beta chainInterleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responsesStructure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragmentThrombopoietin signal transduction requires functional JAK2, not TYK2Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signalingPhosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography.Thrombopoietin.New insights and therapeutics for immune-mediated thrombocytopenia.Pathobiology of secondary immune thrombocytopenia.New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin receptor-stimulating agents.Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents.The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation.Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell lineJanus kinases: components of multiple signaling pathways.Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in ratsDelineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.RNA-seq based transcriptome analysis of hepatitis E virus (HEV) and hepatitis B virus (HBV) replicon transfected Huh-7 cells.Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiationSignals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal.Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivoFunctional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietinControl of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway.A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells.Eltrombopag inhibition of acute myeloid leukemia cell survival does not depend on c-Mpl expression.The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis.Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation.Reconstitution of a cytokine receptor scaffold utilizing multiple different tyrosine motifs.Activation of target signal transducers utilizing chimeric receptors with signaling-molecule binding motifs.Design of conditionally active STATs: insights into STAT activation and gene regulatory function.Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo.Orientation-specific signalling by thrombopoietin receptor dimers.Regulation of polymorphonuclear cell activation by thrombopoietin.Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons.Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5The membrane-proximal region of the thrombopoietin receptor confers its high surface expression by JAK2-dependent and -independent mechanisms.Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.
P2860
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P2860
Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@ast
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@en
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@nl
type
label
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@ast
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@en
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@nl
prefLabel
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@ast
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@en
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@nl
P2093
P2860
P356
P1476
Distinct regions of c-Mpl cyto ...... athway and Shc phosphorylation
@en
P2093
A L Gurney
F J de Sauvage
P2860
P304
P356
10.1073/PNAS.92.12.5292
P407
P577
1995-06-01T00:00:00Z