The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.
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Role of E3 ubiquitin ligases in gastric cancerUbiquitylation, neddylation and the DNA damage responseEpicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiationUbiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancerOvercoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.A metal-based inhibitor of NEDD8-activating enzyme.A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma.Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapyKnockdown of regulator of cullins-1 (ROC1) expression induces bladder cancer cell cycle arrest at the G2 phase and senescence.A role of TGFß1 dependent 14-3-3σ phosphorylation at Ser69 and Ser74 in the regulation of gene transcription, stemness and radioresistanceThe NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabineInactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer.Suppression of glioblastoma by targeting the overactivated protein neddylation pathway.Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agentsMolecular targets and mechanisms of radiosensitization using DNA damage response pathways.Neddylation plays an important role in the regulation of murine and human dendritic cell function.Radiosensitization by the investigational NEDD8-activating enzyme inhibitor MLN4924 (pevonedistat) in hormone-resistant prostate cancer cells.MicroRNA-17-5p regulated apoptosis-related protein expression and radiosensitivity in oral squamous cell carcinoma caused by betel nut chewing.Suppression of tumor angiogenesis by targeting the protein neddylation pathway.MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy.Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases.Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.Flipping the switch from g1 to s phase with e3 ubiquitin ligasesMLN4924 therapy as a novel approach in cancer treatment modalities.Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924).Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice.Overactivated neddylation pathway as a therapeutic target in lung cancer.MicroRNA-17-5p post-transcriptionally regulates p21 expression in irradiated betel quid chewing-related oral squamous cell carcinoma cells.The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors.MLN4924 and 2DG combined treatment enhances the efficiency of radiotherapy in breast cancer cells.SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses.Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer.Protein neddylation and its alterations in human cancers for targeted therapy.Radiosensitization of Human Colorectal Cancer Cells by MLN4924: An Inhibitor of NEDD8-Activating Enzyme.
P2860
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P2860
The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@ast
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@en
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@nl
type
label
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@ast
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@en
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@nl
prefLabel
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@ast
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@en
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@nl
P2093
P2860
P1433
P1476
The p21-dependent radiosensiti ...... or of NEDD8 activating enzyme.
@en
P2093
Gongxian Wang
Mingjia Tan
P2860
P304
P356
10.1371/JOURNAL.PONE.0034079
P407
P577
2012-03-22T00:00:00Z