Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma - Wikidata - thesis-toulmin - TriplyDB

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma

http://www.wikidata.org/entity/Q34246014

about

The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair Genetics and biology of pancreatic ductal adenocarcinoma Emerging role of Hippo pathway in gastric and other gastrointestinal cancers GEMMs as preclinical models for testing pancreatic cancer therapies A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor.Yes-Associated Protein Expression Is Correlated to the Differentiation of Prostate Adenocarcinoma.Hippo pathway mediates resistance to cytotoxic drugs.Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1.The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells.Disease implications of the Hippo/YAP pathway.Hippo signaling pathway in liver and pancreas: the potential drug target for tumor therapy.Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling.TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation.Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma The emerging roles of YAP and TAZ in cancer YAP controls retinal stem cell DNA replication timing and genomic stability.Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression COX-2 dependent regulation of mechanotransduction in human breast cancer cells YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3 Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway A genetic variant in large tumor suppressor kinase 2 of Hippo signaling pathway contributes to prognosis of hepatocellular carcinoma.The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation Study of Clinical Survival and Gene Expression in a Sample of Pancreatic Ductal Adenocarcinoma by Parsimony Phylogenetic Analysis.Cell density regulates cancer metastasis via the Hippo pathway.The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma.Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.

P2860

Q26744308-29E0FE31-3B20-4E03-A6C2-03FAF55FAD04 Q26765438-C2E8C405-4F31-49AD-AE93-AF5D23E6B4BC Q26774473-0D48C3C2-3473-4E23-A5DE-827D74B218CB Q26781848-4082C2B3-C43C-479A-8C6F-3992704B7751 Q26782842-578161D7-B157-4616-8B50-227E8FA59D08 Q28078129-36DF0354-07FC-423E-B375-1355232D8069 Q28269498-81C59E77-9352-49A0-B3BC-98696DAE4BDC Q30369861-C751303F-6C19-48D3-ABE3-045FD836247F Q33925616-65F28413-6A37-4144-B407-61A3BDF2B7F2 Q34555337-0C46CCC1-23F5-4012-B6AC-1CEFD06C81F9 Q35172929-6D5E083D-98CF-4866-AB69-90C08B7582E9 Q35214708-098DEBFB-DD13-4F2D-BA03-847AA78584E3 Q35269102-ED00AE16-926D-42BB-838E-79C2EFA93EBE Q35484837-E5A54847-D9EC-4C3A-81A5-11529280AB5D Q35577502-2B4168BF-80CE-45EB-A289-5465B90F6A86 Q35615595-2CF9EB1B-2A8F-4C84-B945-25672747F693 Q35742523-1E1391DA-8164-4425-91CA-77A57818D04D Q35818801-48308E71-D49B-497A-9B58-D28C3AC3B1ED Q35954277-9B08B538-4C2B-47A3-ACC4-4CEAD5DBF8E4 Q36035567-3643BABC-6F7C-4E32-AF3B-32B508772707 Q36081457-93DDE4A6-D6C4-4C6C-B10F-A4A733A47940 Q36117713-5AD4E5F5-FF7B-447F-89A5-D43D48A3B9CE Q36214324-2D80AB5A-52AF-4E2A-99A6-36CD1EA1D4B6 Q36219267-E328A553-3D49-49AA-98EE-24B4BEB8CC47 Q36273267-59547044-5577-4AD6-AD65-249F478EE125 Q36280897-F550AB33-C648-4DA1-A9A3-44CCC3D4C5BF Q36398735-98F24EE4-82AF-4E58-B6CA-E904E6EABB7D Q36546520-5D78A697-20D9-4F6A-944C-FC4D3DF45B03 Q36546544-2B234428-3788-412F-BCB2-A1AC0457112D Q36689006-E0A0DF1D-BB99-4327-AAB5-8A2732788DFD Q36798037-7EB870BD-6AF6-4930-A485-3A6D92E7AA86 Q37058831-EFA43943-911D-43DB-8B3D-745E081F4EF5 Q37120442-6421C2D2-A3C4-4036-9000-A1A1588618D5 Q37141896-67E8E9CD-369C-4EE4-B4B3-C7F086D8498D Q37158424-BA321BD0-9FBC-40B9-AB7D-87BA6D2ADBF3 Q37199465-F0CDEEAB-04D8-4AEE-AEDA-9758940E2C8F Q37273793-A9A16C22-253A-4A02-B959-46E91A48660B Q37306997-508D148B-8BD8-4D47-B3C8-A61220BA3EB8 Q37352098-B78D8767-B524-4627-A3A1-31E7D6EC50C8 Q37612660-D2236BDB-B658-430B-AF1B-8585C75C9D8A

P2860

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma

http://www.wikidata.org/entity/Q34246014

description

2014 nî lūn-bûn

@nan

2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@ast

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@en

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@nl

type

label

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@ast

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@en

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@nl

prefLabel

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@ast

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@en

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@nl

P1433

Q34246014-F804A064-7E86-4F09-A5BE-7CA8C8352F3A

P1476

Q34246014-22817B53-2464-4BCF-BEC5-490FC2F105AA

P2093

Q34246014-14042C62-1BE2-45EC-8BC5-8B1B41369935

Q34246014-2987020E-44B6-4617-A34F-3721F36C43CA

Q34246014-2D6DAD0A-E864-4AA1-8C18-64C8C443C72B

Q34246014-34A04AA1-CDB1-465A-B534-A473CB5FC7F6

Q34246014-3B7119B9-8235-4F21-B86F-C69D953C9F34

Q34246014-4EB82089-8FB2-4278-AA46-5C72E18E4F26

Q34246014-569FD98F-A1CC-4C17-BD77-EEB6F2D38820

Q34246014-6D6D52B5-7A9F-4E48-A83F-D74283DE534E

Q34246014-8E7E36BE-9445-44D2-A8C8-16F7CFFAC9F1

Q34246014-ADEFA768-5560-4545-835C-22E6FD2E2C4E

P2860

Q34246014-00F5B4C3-140A-4900-8EAB-AAE0BE0B57BF

Q34246014-01170813-CD59-4FC6-A0E4-49337EC44FBC

Q34246014-011BCCE7-D4C1-4203-A874-4EBCC734AB31

Q34246014-024ACE28-DE17-42A9-BC0A-D76143C434F1

Q34246014-04174DAC-A596-4F9A-9B21-0B54B72AFC24

Q34246014-04B071B8-1E21-4EA3-8C93-94028607C3F0

Q34246014-0626D3F5-5713-41A6-9456-C95C7DD83924

Q34246014-07BFAEF6-7A58-4D0B-8DF4-D2179BB2F37A

Q34246014-0EED92B0-DB5A-4B0E-AAD3-5AAC78D0B2D0

Q34246014-0FF9CAC3-14D1-4035-8021-1C49DAD8A093

P304

Q34246014-EECD0689-E948-44F1-A51D-2DF20F6A4B6C

P31

Q34246014-89E8A76D-DE26-4D3A-AE70-A39FDB81BA43

P356

Q34246014-B2B05197-A539-4B5B-94BF-B7AC58A39F09

P433

Q34246014-75F18B0C-3ABD-4EDD-83B7-B8F60D377086

P478

Q34246014-6713820D-6777-4719-B5BC-6D61C5E48FA7

P50

Q34246014-0B527484-E105-4174-BAEE-7C45AF8F9EEC

Q34246014-2FD09B19-87E3-4CA9-91DA-AB9005E3E76B

P577

Q34246014-3D0BC5E7-E171-4289-BE4A-4A7B691893BB

P5875

Q34246014-EA33C651-AB1E-46D4-B6FE-FEC050E6274F

P698

Q34246014-AA78DD5B-4CC7-423F-ABBD-058A6C0060DC

P921

Q34246014-E3471CA3-1FA7-403C-A8F0-8D8AF81ECFBF

P932

Q34246014-B9787B20-797D-45E1-B845-49DD03A6CC50

P356

SCISIGNAL.2005049

P1433

Science Signaling

P1476

Downstream of mutant KRAS, the ...... ncreatic ductal adenocarcinoma

@en

P2093

Alias Smith

http://www.w3.org/2001/XMLSchema#string

Bhaskar Kallakury

http://www.w3.org/2001/XMLSchema#string

Chunling Yi

http://www.w3.org/2001/XMLSchema#string

Eveline E Vietsch

http://www.w3.org/2001/XMLSchema#string

Fen Wang

http://www.w3.org/2001/XMLSchema#string

Jeffrey Toretsky

http://www.w3.org/2001/XMLSchema#string

Mahandranauth Chetram

http://www.w3.org/2001/XMLSchema#string

Mandheer Wadhwa

http://www.w3.org/2001/XMLSchema#string

Mark Manzano

http://www.w3.org/2001/XMLSchema#string

Mrinmayi Joshi

http://www.w3.org/2001/XMLSchema#string

P2860

Bioconductor: open software development for computational biology and bioinformatics

Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis

TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions

Tumor suppressor LATS1 is a negative regulator of oncogene YAP

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

TEAD mediates YAP-dependent gene induction and growth control

A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer

P304

ra42

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1126/SCISIGNAL.2005049

http://www.w3.org/2001/XMLSchema#string

P433

324

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

Anton Wellstein

Garrett T Graham

P577

2014-05-06T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

262112553

http://www.w3.org/2001/XMLSchema#string

P698

24803537

http://www.w3.org/2001/XMLSchema#string

P921

P932

4175524

http://www.w3.org/2001/XMLSchema#string