Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of RANKL
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Can heparins stimulate bone cancer stem cells and interfere with tumorigenesis?Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myelomaInvolvement of heparanase in atherosclerosis and other vessel wall pathologiesHeparanase enhances myeloma progression via CXCL10 downregulation.Breast cancer metastasis to the bone: mechanisms of bone lossHeparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activityHeparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotypeMyeloma cell-derived Runx2 promotes myeloma progression in bone.Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancerHeparan sulfate chains of syndecan-1 regulate ectodomain shedding.FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells.The potential of heparanase as a therapeutic target in cancerFibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions.Heparanase regulates secretion, composition, and function of tumor cell-derived exosomesHeparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cellsHeparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease.Heparanase promotes radiation resistance of cervical cancer by upregulating hypoxia inducible factor 1.Heparanase overexpression down-regulates syndecan-1 expression in a gallbladder carcinoma cell line.The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 ExpressionAdipocyte-Lineage Cells Support Growth and Dissemination of Multiple Myeloma in Bone.Heparanase Upregulation Contributes to Porcine Reproductive and Respiratory Syndrome Virus Release.Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma.NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma.Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.Phosphomannopentaose sulfate (PI-88) suppresses angiogenesis by downregulating heparanase and vascular endothelial growth factor in an oxygen-induced retinal neovascularization animal model.Heparanase: From basic research to therapeutic applications in cancer and inflammation.Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior.Animal Models of Bone Metastasis.Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo.Polymorphisms in the heparanase gene in multiple myeloma association with bone morbidity and survival
P2860
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P2860
Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of RANKL
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Heparanase enhances local and ...... ression and secretion of RANKL
@ast
Heparanase enhances local and ...... ression and secretion of RANKL
@en
Heparanase enhances local and ...... ression and secretion of RANKL
@nl
type
label
Heparanase enhances local and ...... ression and secretion of RANKL
@ast
Heparanase enhances local and ...... ression and secretion of RANKL
@en
Heparanase enhances local and ...... ression and secretion of RANKL
@nl
prefLabel
Heparanase enhances local and ...... ression and secretion of RANKL
@ast
Heparanase enhances local and ...... ression and secretion of RANKL
@en
Heparanase enhances local and ...... ression and secretion of RANKL
@nl
P2093
P2860
P1433
P1476
Heparanase enhances local and ...... ression and secretion of RANKL
@en
P2093
Larry J Suva
Ralph D Sanderson
Vishnu C Ramani
Yongsheng Ren
P2860
P304
P356
10.1158/0008-5472.CAN-10-2179
P407
P577
2010-10-26T00:00:00Z