Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine.
about
CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquineHydroxylated derivatives of NPC1161: theoretical insights into their potential toxicity and the feasibility and regioselectivity of their formationEvaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In VitroPharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines).Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase.Enantioselective metabolism of primaquine by human CYP2D6.Genome-wide patterns of genetic polymorphism and signatures of selection in Plasmodium vivax.Computational Study on the Effect of Exocyclic Substituents on the Ionization Potential of Primaquine: Insights into the Design of Primaquine-Based Antimalarial Drugs with Less Methemoglobin GenerationDifferential CYP 2D6 metabolism alters primaquine pharmacokinetics.Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbanceAntiparasitic chemotherapy: from genomes to mechanisms.Single-cell evaluation of red blood cell bio-mechanical and nano-structural alterations upon chemically induced oxidative stressDifferential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.Synthesis and evaluation of naphthyridine compounds as antimalarial agentsDFT study on the radical anions formed by primaquine and its derivatives.Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsThe metabolism of primaquine to its active metabolite is dependent on CYP 2D6Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.Synthesis of primaquine glyco-conjugates as potential tissue schizontocidal antimalarial agents.Profiling primaquine metabolites in primary human hepatocytes using UHPLC-QTOF-MS with 13C stable isotope labeling.Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometryEnantiospecific pharmacokinetics and drug–drug interactions of primaquine and blood-stage antimalarial drugs
P2860
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P2860
Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@ast
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@en
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@nl
type
label
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@ast
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@en
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@nl
prefLabel
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@ast
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@en
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@nl
P2093
P356
P1476
Primaquine-induced hemolytic a ...... ocytes to 5-hydroxyprimaquine.
@en
P2093
David C McMillan
David J Jollow
Jennifer L Whelan
John E Oatis
Zachary S Bowman
P356
10.1124/JPET.103.062984
P407
P577
2004-01-14T00:00:00Z