Synthesis of quaternary amino acids bearing a (2'Z)-fluorovinyl alpha-branch: potential PLP enzyme inactivators.
about
S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit."Zipped Synthesis" by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model.Efficient synthesis of suitably protected beta-difluoroalanine and gamma-difluorothreonine from L-ascorbic acid.Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.Advances in the synthesis of α-quaternary α-ethynyl α-amino acids.Application of germyldesulfonylation reactions to the synthesis of germanium-containing nucleoside analogues.Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical AdvantagesA useful methoxyvinyl cation equivalent: α-t-butyldimethylsilyl-α-methoxyacetaldehyde.A formal [3,3]-sigmatropic rearrangement route to quaternary alpha-vinyl amino acids: use of allylic N-PMP trifluoroacetimidates.Examination of the new alpha-(2'Z-fluoro)vinyl trigger with lysine decarboxylase: the absolute stereochemistry dictates the reaction course.Julia Olefination as a General Route to Phenyl (alpha-Fluoro)vinyl Sulfones.Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C-SCN and C-C bond formation.Highly E-Selective and Enantioselective Michael Addition to Electron-Deficient Internal Alkynes Under Chiral Iminophosphorane Catalysis.α-Vinylic Amino Acids: Occurrence, Asymmetric Synthesis and Biochemical Mechanisms.Theoretical and X-ray Crystallographic Evidence of a Fluorine-Imine Gauche Effect: An Addendum to Dunathan’s Stereoelectronic Hypothesis
P2860
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P2860
Synthesis of quaternary amino acids bearing a (2'Z)-fluorovinyl alpha-branch: potential PLP enzyme inactivators.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Synthesis of quaternary amino ...... ntial PLP enzyme inactivators.
@ast
Synthesis of quaternary amino ...... ntial PLP enzyme inactivators.
@en
Synthesis of quaternary amino acids bearing a
@nl
type
label
Synthesis of quaternary amino ...... ntial PLP enzyme inactivators.
@ast
Synthesis of quaternary amino ...... ntial PLP enzyme inactivators.
@en
Synthesis of quaternary amino acids bearing a
@nl
prefLabel
Synthesis of quaternary amino ...... ntial PLP enzyme inactivators.
@ast
Synthesis of quaternary amino ...... ntial PLP enzyme inactivators.
@en
Synthesis of quaternary amino acids bearing a
@nl
P2860
P356
P1433
P1476
Synthesis of quaternary amino ...... ential PLP enzyme inactivators
@en
P2093
David B Berkowitz
Roberto de la Salud-Bea
P2860
P304
P356
10.1021/OL049422U
P407
P577
2004-05-01T00:00:00Z