about
G Protein-Coupled Receptors in CancerRole of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapyMelanoma cells break down LPA to establish local gradients that drive chemotactic dispersalMembrane-derived phospholipids control synaptic neurotransmission and plasticityBiochemical and Structural Characterization of Lysophosphatidic Acid Binding by a Humanized Monoclonal AntibodyA metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritisPhosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice.Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafishLysophosphatidic acid signaling in late cleavage and blastocyst stage bovine embryosThe roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expressionLPA receptor signaling: pharmacology, physiology, and pathophysiology.Lysophosphatidic acid plasma concentrations in healthy subjects: circadian rhythm and associations with demographic, anthropometric and biochemical parameters.Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody responseDesign and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.Lysophosphatidic acid in atherosclerotic diseasesAutotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma.Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design.The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulationLysophosphatidic acid enhances stromal cell-directed angiogenesis.Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS.Krüppel-like factor 5 incorporates into the β-catenin/TCF complex in response to LPA in colon cancer cells.Effects of lysophospholipids on tumor microenvironmentUncovering unique roles of LPA receptors in the tumor microenvironment.LPA Promotes T Cell Recruitment through Synthesis of CXCL13.HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer.Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering.Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity.Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration.PPAR γ Networks in Cell Signaling: Update and Impact of Cyclic Phosphatidic Acid.Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD.Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5.Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Aiming drug discovery at lysophosphatidic acid targets.
@ast
Aiming drug discovery at lysophosphatidic acid targets.
@en
Aiming drug discovery at lysophosphatidic acid targets.
@nl
type
label
Aiming drug discovery at lysophosphatidic acid targets.
@ast
Aiming drug discovery at lysophosphatidic acid targets.
@en
Aiming drug discovery at lysophosphatidic acid targets.
@nl
prefLabel
Aiming drug discovery at lysophosphatidic acid targets.
@ast
Aiming drug discovery at lysophosphatidic acid targets.
@en
Aiming drug discovery at lysophosphatidic acid targets.
@nl
P2860
P921
P1476
Aiming drug discovery at lysophosphatidic acid targets.
@en
P2093
Gabor Tigyi
P2860
P304
P356
10.1111/J.1476-5381.2010.00815.X
P407
P577
2010-09-01T00:00:00Z