Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
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The hedgehog pathway in triple-negative breast cancerBromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System TumorsHedgehog signaling: modulation of cancer properies and tumor mircroenvironmentOpen access chemical probes for epigenetic targetsClinical Implications of Hedgehog Pathway Signaling in Prostate CancerNon-Canonical Hh Signaling in Cancer-Current Understanding and Future DirectionsThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseThe Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human CancerCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapySmoothened variants explain the majority of drug resistance in basal cell carcinomaFunctions of BET proteins in erythroid gene expressionTargeting BET bromodomains for cancer treatmentAn In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene ExpressionDYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistanceIntegrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid TumorsThe BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape.Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1Genetic and molecular alterations across medulloblastoma subgroupsBromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth.The Hedgehog pathway: role in cell differentiation, polarity and proliferationSmall molecule Hedgehog pathway antagonists.Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins.Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins.Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.Thin and thick primary cutaneous melanomas reveal distinct patterns of somatic copy number alterations.Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agentsThe BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.Erythropoiesis provides a BRD's eye view of BET protein function.BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signalingTargeting BET bromodomain proteins in solid tumorsSelective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.Epigenetic pathways and glioblastoma treatment: insights from signaling cascades.Molecular biology of pediatric brain tumors and impact on novel therapies.Hedgehog signaling in cancer stem cells: a focus on hematological cancers.
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P2860
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@ast
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@en
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@nl
type
label
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@ast
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@en
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@nl
prefLabel
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@ast
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@en
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@nl
P2093
P2860
P50
P356
P1433
P1476
Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.
@en
P2093
Anitha Ponnuswami
Brian A Link
Brian Nguyen
Brianna Balansay
Guillame Bergthold
James E Bradner
Jean Y Tang
Michelle Monje
P2860
P2888
P304
P356
10.1038/NM.3613
P407
P577
2014-06-29T00:00:00Z
P5875
P6179
1045821094