Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index
about
Roles of d-Amino Acids on the Bioactivity of Host Defense PeptidesPeptides and Peptidomimetics for Antimicrobial Drug DesignThe Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer DrugsA Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptorFour complete turns of a curved 3₁₀-helix at atomic resolution: the crystal structure of the peptaibol trichovirin I-4A in a polar environment suggests a transition to α-helix for membrane functionRational design of alpha-helical antimicrobial peptides: do's and don'tsA cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cellsCathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulationAntimicrobial Properties of an Immunomodulator - 15 kDa Human GranulysinA Fourier transformation based method to mine peptide space for antimicrobial activity.Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides.Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach.End-tagging of ultra-short antimicrobial peptides by W/F stretches to facilitate bacterial killing.Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates."Specificity Determinants" Improve Therapeutic Indices of Two Antimicrobial Peptides Piscidin 1 and Dermaseptin S4 Against the Gram-negative Pathogens Acinetobacter baumannii and Pseudomonas aeruginosaDe novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity.Limiting an antimicrobial peptide to the lipid-water interface enhances its bacterial membrane selectivity: a case study of MSI-367Critical interactions in the stability control region of tropomyosin.Cell selectivity and interaction with model membranes of Val/Arg-rich peptides.Hydrophobicity and helicity regulate the antifungal activity of 14-helical β-peptides.Bacterial membrane activity of α-peptide/β-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains.Role of helicity of α-helical antimicrobial peptides to improve specificity.The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy.Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera.The role of hydrophobic amino acid grafts in the enhancement of membrane-disruptive activity of pH-responsive pseudo-peptides.Dynamics and conformational studies of TOAC spin labeled analogues of Ctx(Ile(21))-Ha peptide from Hypsiboas albopunctatus.Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.Antimicrobial and antibiofilm activity of designed and synthesized antimicrobial peptide, KABT-AMP.Rational design of α-helical antimicrobial peptides to target Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: utilization of charge, 'specificity determinants,' total hydrophobicity, hydrophobe type and location as desigAdaptive evolution of Escherichia coli to an α-peptide/β-peptoid peptidomimetic induces stable resistance.Structure-guided RP-HPLC chromatography of diastereomeric α-helical peptide analogs substituted with single amino acid stereoisomersBacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity.Antiplasmodial properties of acyl-lysyl oligomers in culture and animal models of malaria.Synergistic interaction of PMAP-36 and PRW4 with aminoglycoside antibiotics and their antibacterial mechanism.Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptidesStructure-activity relationship study of novel peptoids that mimic the structure of antimicrobial peptides.Anti-tuberculosis activity of α-helical antimicrobial peptides: de novo designed L- and D-enantiomers versus L- and D-LL-37.Prokaryotic expression and mechanism of action of α-helical antimicrobial peptide A20L using fusion tagsRole of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.
P2860
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P2860
Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
name
Rational design of alpha-helic ...... specificity/therapeutic index
@ast
Rational design of alpha-helic ...... specificity/therapeutic index
@en
Rational design of alpha-helic ...... specificity/therapeutic index
@nl
type
label
Rational design of alpha-helic ...... specificity/therapeutic index
@ast
Rational design of alpha-helic ...... specificity/therapeutic index
@en
Rational design of alpha-helic ...... specificity/therapeutic index
@nl
prefLabel
Rational design of alpha-helic ...... specificity/therapeutic index
@ast
Rational design of alpha-helic ...... specificity/therapeutic index
@en
Rational design of alpha-helic ...... specificity/therapeutic index
@nl
P2093
P2860
P356
P1476
Rational design of alpha-helic ...... specificity/therapeutic index
@en
P2093
Colin T Mant
Michael L Vasil
Robert S Hodges
Susan W Farmer
Yuxin Chen
P2860
P304
12316-12329
P356
10.1074/JBC.M413406200
P407
P577
2005-01-27T00:00:00Z