Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.
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COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phaseObscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnoverMultiple Roles of the Small GTPase Rab7Cullin-RING ligases in regulation of autophagyOngoing controversies surrounding cardiac remodeling: is it black and white-or rather fifty shades of gray?p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stressNeuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclinesRegulation of autophagy by the Rab GTPase networkProteasomal and lysosomal protein degradation and heart disease.The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicityHepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.Neddylation and deneddylation in cardiac biologyAutophagy and p62 in cardiac proteinopathy.miR-34a modulates angiotensin II-induced myocardial hypertrophy by direct inhibition of ATG9A expression and autophagic activityEnhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in miceProteasome functional insufficiency in cardiac pathogenesis.The COP9 signalosome and cullin-RING ligases in the heartMicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death.The COP9 signalosome and vascular function: intriguing possibilities?NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins.Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in mice.COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.Breaking down protein degradation mechanisms in cardiac muscle.The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapyThe COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice.Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner.Posttranslational modification and quality control.The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model.Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways.Ubiquitin and ubiquitin-like proteins in cardiac disease and protection.Methodological approaches and insights on protein aggregation in biological systems.COP9 signalosome regulates autophagosome maturationAutophagy modulation: a potential therapeutic approach in cardiac hypertrophy.Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload.Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy.Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.Neddylation mediates ventricular chamber maturation through repression of Hippo signaling.
P2860
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P2860
Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@ast
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@en
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@nl
type
label
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@ast
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@en
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@nl
prefLabel
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@ast
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@en
Perturbation of cullin deneddy ...... ilated cardiomyopathy in mice.
@nl
P2093
P2860
P1433
P1476
Perturbation of cullin deneddy ...... dilated cardiomyopathy in mice
@en
P2093
Asangi R Kumarapeli
Jinbao Liu
Suchithra Menon
P2860
P356
10.1161/CIRCRESAHA.110.230607
P50
P577
2010-11-04T00:00:00Z