Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease.
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Astrocytes conspire with neurons during progression of neurological diseaseThe role of inflammasome in Alzheimer's diseaseFingolimod for the treatment of neurological diseases-state of play and future perspectivesEarly activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampiNeutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD MouseExosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease.A potent sphingomyelinase inhibitor from Cordyceps mycelia contributes its cytoprotective effect against oxidative stress in macrophagesNFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway.A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease.Structural characterization and antioxidative activity of low-molecular-weights beta-1,3-glucan from the residue of extracted Ganoderma lucidum fruiting bodiesS14G-humanin inhibits Aβ1-42 fibril formation, disaggregates preformed fibrils, and protects against Aβ-induced cytotoxicity in vitro.Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's diseaseAstrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease.Morphometric assessment of toxicant induced neuronal degeneration in full and restricted contact co-cultures of embryonic cortical rat neurons and astrocytes: using m-Dinitrobezene as a model neurotoxicant.Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's DiseaseComputational modeling of sphingolipid metabolism.α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin NeurotoxicitySphingolipid and ceramide homeostasis: potential therapeutic targets.Global changes of phospholipids identified by MALDI imaging mass spectrometry in a mouse model of Alzheimer's disease.Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD).Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer's Disease.The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden.Gemfibrozil, a lipid-lowering drug, induces suppressor of cytokine signaling 3 in glial cells: implications for neurodegenerative disordersTesting NF-κB-based therapy in hemiparkinsonian monkeysSuppression of nuclear factor-κB activation and inflammation in microglia by physically modified saline.Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes.Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic miceGemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy.Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defenseLymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal deathSodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapyUp-regulation of ciliary neurotrophic factor in astrocytes by aspirin: implications for remyelination in multiple sclerosis.Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice.Fluid levity of the cell: Role of membrane lipid architecture in genetic sphingolipidoses.Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1-42-infused mouse model of Alzheimer's disease.Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles.The role of inflammatory processes in Alzheimer's disease.The role of vitamin D in Alzheimer's disease: possible genetic and cell signaling mechanisms.The role of Beta-adrenergic receptor blockers in Alzheimer's disease: potential genetic and cellular signaling mechanisms.
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P2860
Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@ast
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@en
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@nl
type
label
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@ast
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@en
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@nl
prefLabel
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@ast
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@en
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@nl
P2860
P1476
Fibrillar amyloid-beta-activat ...... tions for Alzheimer's disease.
@en
P2093
Arundhati Jana
Kalipada Pahan
P2860
P304
12676-12689
P356
10.1523/JNEUROSCI.1243-10.2010
P407
P577
2010-09-01T00:00:00Z