The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.
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Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cellsHypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1HIF-1: upstream and downstream of cancer metabolismClinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinomaPrognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-AnalysisHypoxia and metabolic adaptation of cancer cellsTargeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer CellsOxygen sensing in retinal health and diseaseLactate shuttles at a glance: from physiological paradigms to anti-cancer treatmentsMechanisms of chemical carcinogenesis in the kidneysHypoxia-inducible factor 1 and cardiovascular diseaseThe Warburg effect revisited--lesson from the Sertoli cellThe altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transportersOn metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancerReexamining cancer metabolism: Lactate production for carcinogenesis could be the purpose and explanation of the Warburg effectLactate as a Signaling Molecule That Regulates Exercise-Induced AdaptationsROS homeostasis and metabolism: a critical liaison for cancer therapyHypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symportersThe roles of phosphate and the phosphate carrier in the mitochondrial permeability transition porePhysical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cellsHypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cellsThe spatial organization of proton and lactate transport in a rat brain tumorThe inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary proteinAR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in miceTissue-specific expression of monocarboxylate transporters during fasting in mice.Exposure to an acute hypoxic stimulus during early life affects the expression of glucose metabolism-related genes at first-feeding in trout.Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHBAstrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions--in silico study supported by in vitro expression dataEffects of intermittent training on anaerobic performance and MCT transporters in athletes.Evaluation of 2-[¹⁸F]fluoroacetate kinetics in rodent models of cerebral hypoxia-ischemiaIntratumoral lactate metabolism in Barrett's esophagus and adenocarcinoma.Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumorsT tubules and surface membranes provide equally effective pathways of carbonic anhydrase-facilitated lactic acid transport in skeletal muscle.In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4Racial disparity in metabolic regulation of cancer.The role of hypoxia inducible factor-1 in hepatocellular carcinoma.Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
P2860
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P2860
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@ast
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@en
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@nl
type
label
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@ast
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@en
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@nl
prefLabel
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@ast
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@en
The plasma membrane lactate tr ...... IF-1alpha-dependent mechanism.
@nl
P2860
P356
P1476
The plasma membrane lactate tr ...... HIF-1alpha-dependent mechanism
@en
P2093
Andrew J Davies
Mohammed S Ullah
P2860
P304
P356
10.1074/JBC.M511397200
P407
P577
2006-02-01T00:00:00Z