The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding.
about
Human Sco1 functional studies and pathological implications of the P174L mutantCopper metallochaperones"Pulling the plug" on cellular copper: the role of mitochondria in copper export.H135A controls the redox activity of the Sco copper center. Kinetic and spectroscopic studies of the His135Ala variant of Bacillus subtilis Sco.Loss of function of Sco1 and its interaction with cytochrome c oxidase.Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis.Loop recognition and copper-mediated disulfide reduction underpin metal site assembly of CuA in human cytochrome oxidaseCOX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux.Function and redox state of mitochondrial localized cysteine-rich proteins important in the assembly of cytochrome c oxidase.Molecular diagnostics and mitochondrial dysfunction: a future perspective.Seeking the determinants of the elusive functions of Sco proteins.Mapping the functional interaction of Sco1 and Cox2 in cytochrome oxidase biogenesis.Novel mutations in SCO1 as a cause of fatal infantile encephalopathy and lactic acidosis.Analysis of copper-ligand bond lengths in X-ray structures of different types of copper sites in proteins.COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.Building the CuA site of cytochrome c oxidase: a complicated, redox-dependent process driven by a surprisingly large complement of accessory proteins.The mitochondrion: a central architect of copper homeostasis.
P2860
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P2860
The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding.
description
2006 nî lūn-bûn
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2006 թվականի մարտին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
The P174L mutation in human Sc ...... oes not impair copper binding.
@ast
The P174L mutation in human Sc ...... oes not impair copper binding.
@en
The P174L mutation in human Sc ...... oes not impair copper binding.
@nl
type
label
The P174L mutation in human Sc ...... oes not impair copper binding.
@ast
The P174L mutation in human Sc ...... oes not impair copper binding.
@en
The P174L mutation in human Sc ...... oes not impair copper binding.
@nl
prefLabel
The P174L mutation in human Sc ...... oes not impair copper binding.
@ast
The P174L mutation in human Sc ...... oes not impair copper binding.
@en
The P174L mutation in human Sc ...... oes not impair copper binding.
@nl
P2093
P2860
P50
P356
P1476
The P174L mutation in human Sc ...... does not impair copper binding
@en
P2093
Dennis R Winge
Eric A Shoubridge
Florin Sasarman
Scot C Leary
P2860
P304
12270-12276
P356
10.1074/JBC.M600496200
P407
P577
2006-03-06T00:00:00Z