Structural basis for depletion of heat shock protein 90 client proteins by deguelin. - Wikidata - thesis-toulmin - TriplyDB

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

http://www.wikidata.org/entity/Q34636939

about

Abronione, a rotenoid from the desert annual Abronia villosa Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway Identification of the plant compound geraniin as a novel Hsp90 inhibitor Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model.Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis.Gambogic acid, a natural product inhibitor of Hsp90 Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms, translational activation and stabilization of HIF-1alpha protein.Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells.Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway.Deguelin induces apoptosis by targeting both EGFR-Akt and IGF1R-Akt pathways in head and neck squamous cell cancer cell lines.The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells.Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy A multiplicity of anti-invasive effects of farnesyl transferase inhibitor SCH66336 in human head and neck cancer.Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion.Regulation of ROS production and vascular function by carbon monoxide Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model Insulin-like growth factor binding protein-3 suppresses vascular endothelial growth factor expression and tumor angiogenesis in head and neck squamous cell carcinoma.Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF.Novel C6-substituted 1,3,4-oxadiazinones as potential anti-cancer agents.Histone deacetylase inhibitors enhance the apoptotic activity of insulin-like growth factor binding protein-3 by blocking PKC-induced IGFBP-3 degradation A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer.Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha.Kava, a tonic for relieving the irrational development of natural preventive agents.Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells.A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation.Hemin, an iron-binding porphyrin, inhibits HIF-1α induction through its binding with heat shock protein 90.Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects.Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition Deguelin and Its Role in Chronic Diseases.Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors.Heat shock proteins and kidney disease: perspectives of HSP therapy.Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system.Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity.High-content screening of drug-induced cardiotoxicity using quantitative single cell imaging cytometry on microfluidic device.Simultaneous quantitative monitoring of drug-induced caspase cascade pathways in carcinoma cells.

P2860

Q24632579-AD51D898-DFAF-4513-B389-FFA3F73E203C Q27312452-E33A8957-64CF-466C-8636-0DC39D0CED2A Q28382812-B8262DCD-1E51-4D02-A44A-1C1D2F755D09 Q28533486-19FBBCAB-0E08-4125-8218-B8F208F0358B Q30530734-A769932D-743E-4591-81DA-CC23430C2D3E Q33779169-435B3187-8FA5-41A5-9E43-6AD666F064C9 Q33870322-21807221-E07A-4AAB-9713-01E25DB7472B Q34186417-58D7BED9-3D24-4E91-98C8-684F55EEC2C0 Q34571304-80D1628E-CBD1-4CF2-9FCD-41DC2236C8CD Q35147446-2F0A72B4-E50F-4390-B149-30B5EF516F41 Q35667885-9DCD3DE4-056A-485C-9B58-276A177FEE81 Q35760966-CA70D860-1A75-4C6A-84B5-5FD5EE58DE14 Q35800838-6198E226-1AA4-4493-A4A3-84F209BCE4FF Q35886681-B0DB94F1-B2C0-45DE-A081-3E6052036B1A Q36031062-F9596522-933D-48C9-9243-22ED675F89BD Q36140879-28A7EA05-5691-4CD9-84F8-9DB7357F0575 Q36183868-D9A3A008-D6CD-4D33-8D2A-F8E44EEBB19C Q36212298-2322999F-13CD-4170-ABD2-14B8E67281DD Q36300954-61CDE238-32BE-447A-9DB9-EAE2C81E4B02 Q36414376-986F90D9-544C-40C3-B93C-4ACCF26EA641 Q36562098-F04B2813-9E4C-4657-9520-E7C74580172B Q36767863-0515EC1C-0862-4D6C-92B2-80C867406084 Q36800387-0FAAD3B2-E851-4045-906C-54CB935CE7D1 Q37077443-3DA5012C-3904-4E46-BD6A-561F575101E1 Q37106192-E874347C-27E9-4B5F-979C-A36F04FCF3E4 Q37175348-01C1869F-1331-4C92-A694-ABBF599C6D0D Q37228635-84142011-88BE-43FD-8A86-CF9441DFCFD0 Q37334829-87D570B0-34CE-4D95-ACA5-40C6966DD02E Q37345190-34502295-DDC2-4809-A23C-B8F8FFEA7BB1 Q37346456-8436CC03-264F-4FD7-BDB0-6A4A6A7E2F0C Q38476087-D2262B55-88CB-49A8-81AC-18910872412E Q38750417-48D76146-55AE-44AF-AE4F-5A9F92BCCD00 Q38823644-5E7D9329-114E-48C7-8811-44B8DCFEB933 Q38988602-7DA55515-F7B4-48C1-9993-74898577B13F Q38990297-170155ED-E137-4984-8018-847ABC7639FE Q39242393-D84BF1A6-5253-42FA-8993-604FB48FFF95 Q39284112-7ED935D6-95C6-47E3-BD15-CADE0B7C72ED Q39382063-080431C9-BC93-4928-A2CE-13B7CB9A09C0 Q39634258-3401A1F5-D719-460E-AE67-AC1111CF7791 Q39703393-4939C310-2415-40F4-9591-831E7A2E6A04

P2860

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

http://www.wikidata.org/entity/Q34636939

description

2007 nî lūn-bûn

@nan

2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@ast

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@en

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@nl

type

label

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@ast

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@en

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@nl

prefLabel

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@ast

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@en

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

@nl

P1433

Q34636939-2A031500-98F6-42B4-A9A1-54AB9FEEC0D9

P1476

Q34636939-0DA2E90D-E927-4D35-AB15-20A83A80903E

P2093

Q34636939-138C2B65-D7F1-4ED2-86B4-3C4AE8139665

Q34636939-36DD3E36-933A-4950-B65B-EAB6A7F8EB0A

Q34636939-4C65A382-F5E4-4AB3-A45E-E06F9BEF0B50

Q34636939-6ABA6D92-ED7C-4FCD-B331-9E5D023C0A8A

Q34636939-70BAC3A7-0D12-484B-A946-8019D1400F82

Q34636939-8473DE09-5701-4D30-A38D-D3107A6B5A6A

Q34636939-93C35987-4D5F-4059-8265-5CFCE8D0F701

Q34636939-AC4E879C-B866-4FF2-9401-93CF07DB772A

Q34636939-D1EFCF3B-D540-4284-99E3-1E8502ED3A53

Q34636939-E4CD9810-D7AB-4185-8910-DE5A431F17BF

P2860

Q34636939-0648DF78-ACB3-4221-9563-02119E6E6522

Q34636939-0DC4634B-6193-42F3-8DBA-F24CAAD18EE7

Q34636939-110C17BB-CD96-4BF4-819C-0B5A96683304

Q34636939-26BD74E2-BB22-4F88-B917-E1BD92F433FB

Q34636939-2D837AF5-8B38-465D-B7A2-088C07C4B7D6

Q34636939-30B52813-672F-46C0-8C92-D85B01E573CE

Q34636939-3196F32B-FAB2-4A8F-B9E7-A53ABA33F9DE

Q34636939-4D80B710-CC46-4343-89B0-5FEDEA167AF6

Q34636939-4F6F77D1-9A67-4BF4-9084-A8A174C07B77

Q34636939-5157DCD7-8E74-479D-9503-2D4D808EC8B8

P304

Q34636939-1066FAF2-31AC-4400-AAE0-2A2AD9B35236

P31

Q34636939-5C64918E-7592-4E3D-B08E-A0C6654B6904

P356

Q34636939-DF524A6F-569F-4573-83D6-52DE03BCED07

P407

Q34636939-7B24F29E-600C-4E43-B39F-F1C16F897F6B

P433

Q34636939-33A4C717-1B8F-4AA8-95B4-E834C27F8DEC

P478

Q34636939-1CFD0502-6F43-4973-B668-407637D8A1E3

P50

Q34636939-90A9D10A-802E-4E30-94BD-0CCC1E932148

P577

Q34636939-CF9A9D28-DCFD-489E-B5FD-4A343DF29CE7

P5875

Q34636939-E8814D96-FCCF-4F6A-B7DE-5E4C6B446DC3

P698

Q34636939-4DF467A0-3AF7-4649-921A-5DA55B9DCB8C

P356

P1433

Journal of the National Cancer Institute

P1476

Structural basis for depletion of heat shock protein 90 client proteins by deguelin

@en

P2093

Ho-Young Lee

http://www.w3.org/2001/XMLSchema#string

Hyun-Ju Park

http://www.w3.org/2001/XMLSchema#string

Jeffrey N Myers

http://www.w3.org/2001/XMLSchema#string

Kyu-Won Kim

http://www.w3.org/2001/XMLSchema#string

Quanri Jin

http://www.w3.org/2001/XMLSchema#string

Seung Hyun Oh

http://www.w3.org/2001/XMLSchema#string

Soon Sun Hong

http://www.w3.org/2001/XMLSchema#string

Waun Ki Hong

http://www.w3.org/2001/XMLSchema#string

Woo-Young Kim

http://www.w3.org/2001/XMLSchema#string

Yasemin Dakak Yazici

http://www.w3.org/2001/XMLSchema#string

P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

Targeting HIF-1 for cancer therapy

Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats

Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells

HIF-1 and tumor progression: pathophysiology and therapeutics

Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells

P304

949-961

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/JNCI/DJM007

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

99

http://www.w3.org/2001/XMLSchema#string

P50

P577

2007-06-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6272206

http://www.w3.org/2001/XMLSchema#string

P698

17565155

http://www.w3.org/2001/XMLSchema#string