The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

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http://www.wikidata.org/entity/Q34655627
Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligandsGRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient MiceTCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction.Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclustersGlycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics.Integrative biology of T cell activation.Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.Development of nanoscale structure in LAT-based signaling complexes.Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation.
P2860

The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

Item
http://www.wikidata.org/entity/Q34655627
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2013 nî lūn-bûn
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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
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2013年論文
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2013年論文
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2013年论文
@wuu
name
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@ast
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@en
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@nl
type
label
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@ast
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@en
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@nl
prefLabel
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@ast
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@en
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P932
P356
P1433
P1476
The ability of Sos1 to oligome ...... ide exchange activity in vivo.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P932