Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules.
about
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28T-cell co-stimulation through B7RP-1 and ICOSGenetics of type 1 diabetes mellitusBoth extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28Molecular characterization and applications of recombinant scFv antibodies to CD152 co-stimulatory molecule.Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands.CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.Ipilimumab augments antitumor activity of bispecific antibody-armed T cellsDifferent cell surface oligomeric states of B7-1 and B7-2: implications for signaling.CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics.Viewpoint: therapeutic implications of CTLA-4 compartmentalization.Antitumor immunopreventive effect in mice induced by DNA vaccine encoding a fusion protein of alpha-fetoprotein and CTLA4.At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapyCoinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections.Alternatives to calcineurin inhibition in renal transplantation: belatacept, the first co-stimulation blocker.Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability.CTLA-4, a negative regulator of T-lymphocyte activation.Structural analysis of natriuretic peptide receptor-C by truncation and site-directed mutagenesis.Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States.Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail.Type-3 BRET, an improved competition-based bioluminescence resonance energy transfer assay.A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.Functional polymorphism in CTLA4 gene influences the response to therapy with inhaled corticosteroids in Slovenian children with atopic asthma.Polymorphism of CTLA-4 gene for major depression in the Korean population.CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation.Evaluation of polymorphism, hypermethylation and expression pattern of CTLA4 gene in a sample of Iranian patients with schizophrenia.Highly sensitive glycosylamine labelling of O-glycans using non-reductive β-elimination.No evidence for an association of the CTLA4 gene with bipolar I disorder.Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy.A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions.Local or short-term systemic costimulatory molecule blockade prolongs rat corneal allograft survival
P2860
Q27740654-C49A5D85-850F-44CC-A668-9B814DF2C411Q28141589-C62CE4A8-7A47-42CD-9B21-48BF96733692Q28215982-6593276F-FA6E-48AB-B02C-C0B122DC7BDEQ28288428-03D8508B-90F3-401E-B0A8-F0C70032B898Q30860559-AF6E6E06-31D4-487F-97CF-A943B50D00DDQ30882706-7BD43962-674A-4845-89BB-7A3CFC1355E1Q33808334-9EFCC7F6-4D62-493E-BC4C-CA8BB7E0D368Q33849223-C91E47DA-0828-4FCE-9215-AF24FF70CBA7Q33929184-E88F1E00-617F-4C03-944E-077FC9269F66Q34098531-86BAEF8D-9717-45D7-9780-0B30A476379AQ34738334-10D997EA-1143-41B2-9873-9DDD155ADC84Q35177419-5C42E000-CBFA-4C6F-97D2-31021A8EC263Q36474380-AE7FD83E-6A8D-44F4-8589-9D0B226F27A4Q36935749-0E82E307-FF39-4E30-991C-EAA34922AA01Q36998864-808C9C8C-0820-490D-AC54-29A3B4ED9369Q37474904-65FE6BED-7D04-48BC-BC82-4ED22FC05F40Q37793216-2F74739C-0AEE-4A11-A9E5-55D91E13D4EEQ39535352-65BFF243-8E40-47F4-85C3-E9DA37E63FACQ41332143-5CE5AF84-392D-43D8-A06D-EB6C510DF033Q41980577-2E17603C-D450-4878-A626-EC7BEB1284C8Q42183002-5B3225D0-1939-432E-91B0-55851CEECBDBQ42676587-B526C1D8-0E4C-4079-8EF9-E62648F4C121Q42708779-0A9ABD2B-B3E5-4C10-A911-903CC16107E1Q45299093-00EE7869-6E4E-4F3F-ACC0-AFEEF4CFB78AQ45713818-49961B0D-19F5-4654-9383-6163FD9943FAQ47608740-CAE1E58F-C289-44E8-8D97-F953793E5A6AQ50125551-1BC85427-FF1D-4484-9085-390BE98FE1A6Q51000594-973BFE60-41F7-459A-9EE7-B3088812444CQ51188868-FE6B1CAD-664D-4937-BC96-35C7CC52E495Q51944794-F1A7782F-D67B-499C-ACB9-6DDD5EDFFDD3Q55283310-D6930F54-45FA-47DC-829C-2C52A40572ABQ55336684-18B75360-C9B4-4093-AFC4-96681E18A3C9Q56902883-46E6F17E-3FCA-48EC-BAA4-DC0356A72CC1
P2860
Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Binding stoichiometry of the c ...... imer binds two CD86 molecules.
@ast
Binding stoichiometry of the c ...... imer binds two CD86 molecules.
@en
Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4
@nl
type
label
Binding stoichiometry of the c ...... imer binds two CD86 molecules.
@ast
Binding stoichiometry of the c ...... imer binds two CD86 molecules.
@en
Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4
@nl
prefLabel
Binding stoichiometry of the c ...... imer binds two CD86 molecules.
@ast
Binding stoichiometry of the c ...... imer binds two CD86 molecules.
@en
Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4
@nl
P2093
P2860
P356
P1476
Binding stoichiometry of the c ...... imer binds two CD86 molecules.
@en
P2093
J Bajorath
J Bradshaw
M Stebbins
P S Linsley
S G Nadler
P2860
P304
15417-15424
P356
10.1074/JBC.270.25.15417
P407
P577
1995-06-01T00:00:00Z