Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein response
about
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network.Arv1 regulates PM and ER membrane structure and homeostasis but is dispensable for intracellular sterol transport.The yeast magmas ortholog pam16 has an essential function in fermentative growth that involves sphingolipid metabolism.High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions.Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungiNeuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy.Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeastDeletion of murine Arv1 results in a lean phenotype with increased energy expenditure.Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence.A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistanceMolecular biology of atherosclerosis.Storage lipids of yeasts: a survey of nonpolar lipid metabolism in Saccharomyces cerevisiae, Pichia pastoris, and Yarrowia lipolytica.Eating the Dead to Keep Atherosclerosis at Bay.Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytesSphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis.BiP-bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response.An ARV1 homologue from a filarial nematode is functional in yeast.Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
P2860
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P2860
Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein response
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Loss of subcellular lipid tran ...... the unfolded protein response
@ast
Loss of subcellular lipid tran ...... the unfolded protein response
@en
Loss of subcellular lipid tran ...... the unfolded protein response
@nl
type
label
Loss of subcellular lipid tran ...... the unfolded protein response
@ast
Loss of subcellular lipid tran ...... the unfolded protein response
@en
Loss of subcellular lipid tran ...... the unfolded protein response
@nl
prefLabel
Loss of subcellular lipid tran ...... the unfolded protein response
@ast
Loss of subcellular lipid tran ...... the unfolded protein response
@en
Loss of subcellular lipid tran ...... the unfolded protein response
@nl
P2093
P2860
P356
P1476
Loss of subcellular lipid tran ...... the unfolded protein response
@en
P2093
Andrew B Munkacsi
Annette L Henneberry
Arthur H Tinkelenberg
Caryn F Shechtman
Eunjee Lee
Harmen J Bussemaker
Lisa J Wilcox
Mina Fazlollahi
Stephen L Sturley
P2860
P304
11951-11959
P356
10.1074/JBC.M110.215038
P407
P577
2011-01-25T00:00:00Z