Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.
about
Translational challenges of animal models in Chagas disease drug development: a reviewNovel amidines and analogues as promising agents against intracellular parasites: a systematic reviewMechanisms of Trypanosoma cruzi persistence in Chagas diseaseA new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imagingCD8+ T cells in Trypanosoma cruzi infectionModulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas diseaseIn vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compoundsEffector memory Th1 CD4 T cells are maintained in a mouse model of chronic malariaCombined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivoIn vitro and in vivo studies for assessing the immune response and protection-inducing ability conferred by Fasciola hepatica-derived synthetic peptides containing B- and T-cell epitopesHigh throughput screening for anti-Trypanosoma cruzi drug discoveryAptamer-based detection of disease biomarkers in mouse models for chagas drug discoveryProteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sicknessProfile of central and effector memory T cells in the progression of chronic human chagas diseaseChanges in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi.Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus.Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responses.Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.Altered T cell memory and effector cell development in chronic lymphatic filarial infection that is independent of persistent parasite antigen.CD8(+) T cell-mediated immunity during Trypanosoma cruzi infection: a path for vaccine development?Methodological advances in drug discovery for Chagas disease.Parasitic loads in tissues of mice infected with Trypanosoma cruzi and treated with AmBisome.Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatmentImpact of aetiological treatment on conventional and multiplex serology in chronic Chagas disease.3-Hydroxy kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of chronic Chagas disease.Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.Regulation of CD8+ T cell responses to infection with parasitic protozoa.Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogenCurrent and developing therapeutic agents in the treatment of Chagas diseaseBlood leukocytes from benznidazole-treated indeterminate chagas disease patients display an overall type-1-modulated cytokine profile upon short-term in vitro stimulation with Trypanosoma cruzi antigens.The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8⁺ T cells.Role of the NF-κB transcription factor c-Rel in the generation of CD8+ T-cell responses to Toxoplasma gondii.Protective antigen-independent CD8 T cell memory is maintained during {gamma}-herpesvirus persistenceGenetic dissection of drug resistance in trypanosomesFertility, gestation outcome and parasite congenital transmissibility in mice infected with TcI, TcII and TcVI genotypes of Trypanosoma cruzi.Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease.Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8(+) T effector memory cells specific for a human parasite, Trypanosoma cruziEvaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review.Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade.
P2860
Q26796451-79489DEB-CC83-4BE3-A8DA-3C03617E14B7Q26825025-603FA4DB-37E7-41B2-9035-0139257B8F0BQ26858780-5701486F-0A77-406C-A00A-E0F7F0EA505AQ27011506-203E4A6E-1005-4D8A-8B7B-87CB232A3069Q28081766-0C80C030-6CA2-45C1-B3A7-6096820CB37DQ28083346-E8034BF2-4E3E-4734-BE17-CD6452D07BF6Q28474813-60A02FE9-7824-41DB-AE52-035EF90D8BF4Q28476346-BD4F1F24-A320-4320-8E6B-A1AA3A3D8428Q28479294-4D810364-0D37-4D12-B745-F91F69997172Q28541967-1E78686F-539E-426D-8EC9-5AA2017B2308Q28542489-53282956-30FD-4A48-9F73-35A3F9414955Q28542996-DE92FFC3-C4BA-4FA6-8E90-6C0ABE679740Q28817181-85A97AAB-8147-4832-AB6D-471A45BA801EQ33501719-93C12D07-87E5-4DD9-AAD9-4A26BC353C25Q33585491-3316F35D-BD4B-4A60-B1F1-551571439E06Q33719577-64BC28C2-BF18-49E5-BBAA-2E8FE1D06CD9Q33749707-6B1C065D-1178-4F35-B99B-252B0DEAA324Q33809905-947A07F4-AFB3-438C-989B-E57276E6F0E4Q33861565-9D4B713F-B971-4F5C-8BEC-1856ED286BA5Q33895052-DB60C325-9A87-40F8-ABA5-05DC7B8ADF52Q33914939-AAE0A4B1-08ED-4726-B084-468DB9F65E2AQ33945347-061D1D35-0A8E-45DE-8699-E1703C402000Q33955428-70D9650E-39E6-4A61-937F-F30507BD66BEQ33962768-51E5E4C2-66E5-4A76-9B65-8437946EB4E7Q34016698-9A62656A-7CA7-4511-8BC6-97BAFB8AC42FQ34058668-2CBD9133-16F8-439B-9785-45086615BC67Q34105267-98018759-204D-4B1B-8FEA-1B469719705FQ34108177-89E1C753-33F4-46B7-B3B8-B561946DE33AQ34164082-9766E4AB-1CA2-4995-B2D4-038E1AF5097BQ34170132-A4551CD7-DF2C-4360-9AF0-436B6AA2D4D3Q34280628-D237D4B1-05D1-48D9-A8C7-63F8AC5EC9D2Q34324298-47F1E1FD-D924-480F-BA9E-620A2BDDBF3CQ34365047-9512BE12-8185-4C7A-97EF-FC930CA8268AQ34602206-2648437B-D792-4B84-87E5-8638A39EE1C2Q34647009-8EB93CAE-6267-49C9-B711-320CB6A43E58Q34779055-6B11604E-9AB4-4B8A-B662-7804AE415ED2Q34874190-F474626E-C31E-4DAC-8985-0658F2572179Q34931648-50144B4F-DAA2-4BC9-86B8-11790F453985Q34992879-13E90046-59AB-4716-8AF2-216B8505819DQ35021925-2954CEBB-8037-4A71-ADAE-EA2C3E7247BF
P2860
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@ast
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@en
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@nl
type
label
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@ast
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@en
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@nl
prefLabel
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@ast
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@en
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@nl
P2860
P356
P1433
P1476
Drug-induced cure drives conve ...... nse in chronic Chagas disease.
@en
P2093
Juan M Bustamante
Lisa M Bixby
P2860
P2888
P304
P356
10.1038/NM1744
P407
P5008
P577
2008-04-20T00:00:00Z