Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells
about
The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathyCardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.Cardiac Myosin Binding Protein-C Phosphorylation Modulates Myofilament Length-Dependent ActivationTitin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.Slowing of contractile kinetics by myosin-binding protein C can be explained by its cooperative binding to the thin filament.Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filamentsA post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylationPhosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filamentsCardiac cytoarchitecture - why the "hardware" is important for heart function!Myosin and Actin Filaments in Muscle: Structures and Interactions.Overview of the Muscle Cytoskeleton.Myofilament protein dynamics modulate EAD formation in human hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle.The Conformation of Myosin Heads in Relaxed Skeletal Muscle: Implications for Myosin-Based Regulation.Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.Regulation of Contraction by the Thick Filaments in Skeletal Muscle.Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner.Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.The HCM-linked W792R mutation in cardiac myosin binding protein-C reduces C6 FnIII domain stability.Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task.Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions
P2860
Q35147071-C2A352DF-59AD-4418-8FF2-8A1388300A5CQ36444026-11888143-91CA-4E5D-BD81-FDDDE5DB7114Q36579173-DCE03FD3-FAF7-40DE-8064-EE1EC1ACEBA7Q36646689-450FDC2E-78C0-4950-84D6-6B8C4B180DDEQ36782878-0D1BB907-ABB5-4076-96E8-1FC8E0BA35B6Q36957331-EE4D8DBB-BA69-4687-99F3-790AD0962C7FQ37218043-BB221D75-4EEA-43BA-BC50-1E156676E9E3Q37682309-AC0E0B08-9B5C-4C1F-85A1-E5648A5FBBDBQ38636004-D6C1F17B-1898-4804-B4A1-1E9891CB9802Q39094611-96CF043E-1FE2-443A-9941-2163F97C984CQ39391006-EA54B0F1-F28B-4CB8-BC31-560E19DD51C3Q39397322-3A7376B0-1BF6-4A7F-9949-2F7EA1B51E52Q39440818-68A422FD-1845-4CD1-B396-1424B2D51F8FQ41013371-3D3E3F8B-CD6E-4D6F-9DA5-2CD91B84A0FFQ41957734-847418DE-A25D-49D7-BB7B-1AF7A0F79B6FQ42578168-39D59961-B5ED-4EF3-832F-2D385D391843Q47102056-22432437-DC7B-43DD-9EDC-E6E5F1EF114BQ47270685-6D38AA76-8895-403A-B5F2-B43F6289A89BQ49336760-F7BBAF9B-9137-4CB5-B353-A500E9699FBCQ49923294-F7DF784E-E1E5-4F57-BB89-B57EDB0AF5BEQ49926548-0071AA81-3777-4EDF-8C4D-5B5946BA676AQ55385445-FE0E42B5-B0D2-4767-B6E9-E88BBAD6CC38Q57157253-957A3D42-5F40-4808-B585-BEC305CCEB01
P2860
Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells
description
2014 nî lūn-bûn
@nan
2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@ast
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@en
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@nl
type
label
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@ast
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@en
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@nl
prefLabel
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@ast
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@en
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@nl
P2093
P2860
P356
P1476
Myosin binding protein-C activ ...... ilaments in heart muscle cells
@en
P2093
Malcolm Irving
Thomas Kampourakis
Ziqian Yan
P2860
P304
18763-18768
P356
10.1073/PNAS.1413922112
P407
P577
2014-12-15T00:00:00Z