Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay.
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondMuddled mechanisms: recent progress towards antimalarial target identificationGametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient dataEnlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied researchGametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activityIdentification of MMV Malaria Box inhibitors of Perkinsus marinus using an ATP-based bioluminescence assayPlasmodium falciparum transfected with ultra bright NanoLuc luciferase offers high sensitivity detection for the screening of growth and cellular trafficking inhibitorsA New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug DiscoveryScreening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar EchinococcosisBilayer Effects of Antimalarial CompoundsBiological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathwayDiverse chemotypes disrupt ion homeostasis in the Malaria parasite.Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.Developing transmission-blocking strategies for malaria control.Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations.Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum.Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives.Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.Identification of β-hematin inhibitors in the MMV Malaria BoxSplenic retention of Plasmodium falciparum gametocytes to block the transmission of malariaA simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compoundsA semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes.Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte developmentPlasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.An ultrasensitive NanoLuc-based luminescence system for monitoring Plasmodium berghei throughout its life cycleMetabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.SC83288 is a clinical development candidate for the treatment of severe malaria.The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes.Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis.A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays.Multicolor bioluminescence boosts malaria research: quantitative dual-color assay and single-cell imaging in Plasmodium falciparum parasitesHexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions.Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates.A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugs.
P2860
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P2860
Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay.
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Identification of MMV malaria ...... e-based high-throughput assay.
@ast
Identification of MMV malaria ...... e-based high-throughput assay.
@en
Identification of MMV malaria ...... e-based high-throughput assay.
@nl
type
label
Identification of MMV malaria ...... e-based high-throughput assay.
@ast
Identification of MMV malaria ...... e-based high-throughput assay.
@en
Identification of MMV malaria ...... e-based high-throughput assay.
@nl
prefLabel
Identification of MMV malaria ...... e-based high-throughput assay.
@ast
Identification of MMV malaria ...... e-based high-throughput assay.
@en
Identification of MMV malaria ...... e-based high-throughput assay.
@nl
P2860
P50
P356
P1476
Identification of MMV malaria ...... e-based high-throughput assay.
@en
P2093
Leonardo Lucantoni
Sophie H Adjalley
P2860
P304
P356
10.1128/AAC.00870-13
P407
P577
2013-09-23T00:00:00Z