Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans
about
Pancreatic regulation of glucose homeostasisMultiple roles for the actin cytoskeleton during regulated exocytosisCyclic AMP dynamics in the pancreatic β-cellGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesGlucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytescAMP induces stromal interaction molecule 1 (STIM1) puncta but neither Orai1 protein clustering nor store-operated Ca2+ entry (SOCE) in islet cells.Cyclic AMP sensor EPAC proteins and energy homeostasis.Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S.The future of EPAC-targeted therapies: agonism versus antagonismCoupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysisRp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Role of phospholipase Cε in physiological phosphoinositide signaling networks.Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2Aβ-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis.Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.Regulation of the inflammatory response of vascular endothelial cells by EPAC1.New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout miceThe proteins of exocytosis: lessons from the sperm model.U-73122 reduces the cell growth in cultured MG-63 ostesarcoma cell line involving Phosphoinositide-specific Phospholipases C.Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts.Epac2A makes a new impact in β-cell biology.PACAP signaling in stress: insights from the chromaffin cell.β-Cell signalling and insulin secretagogues: A path for improved diabetes therapy.CB1 receptors down-regulate a cAMP/Epac2/PLC pathway to silence the nerve terminals of cerebellar granule cells.Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Glucotoxicity inhibits cAMP-protein kinase A-potentiated glucose-stimulated insulin secretion in pancreatic β-cells.
P2860
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P2860
Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans
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2011 nî lūn-bûn
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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2011 թվականի մայիսին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans
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Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans
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Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans
@ast
Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans
@en
prefLabel
Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans
@ast
Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans
@en
P2093
P2860
P356
P1433
P1476
Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans
@en
P2093
Alan V Smrcka
Colin A Leech
Elvira Dzhura
Frank Schwede
George G Holz
Hans-G Genieser
Igor Dzhura
Michael W Roe
Oleg G Chepurny
P2860
P304
P356
10.4161/ISL.3.3.15507
P577
2011-05-01T00:00:00Z