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Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotypeStructural basis of selective ubiquitination of TRF1 by SCFFbx4Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch IIA novel switch region regulates H-ras membrane orientation and signal outputThe scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell deathKappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelAPhosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loopExpression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPaseThe distinct conformational dynamics of K-Ras and H-Ras A59GRas Homolog Enriched in Brain (Rheb) Enhances Apoptotic SignalingStructural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarityAnalysis of Binding Site Hot Spots on the Surface of Ras GTPaseA Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected].Ras membrane orientation and nanodomain localization generate isoform diversityNew insight into the dynamic properties and the active site architecture of H-Ras p21 revealed by X-ray crystallography at very high resolutionThe Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology.Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complexThe Interplay between ROS and Ras GTPases: Physiological and Pathological Implications.The emerging role of the RAB25 small GTPase in cancerA Homogenous Bioluminescent System for Measuring GTPase, GTPase Activating Protein, and Guanine Nucleotide Exchange Factor Activities.Oncogenic Ras in tumour progression and metastasis.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsRLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution.Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins.K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.Ras nanoclusters: molecular structure and assemblyExpansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutationsAtorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cells.Isoform-specific ras functions in development and cancer.Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.Mechanisms of Ras membrane organization and signalling: Ras on a rocker.Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation.The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation.Inhibition and termination of physiological responses by GTPase activating proteins.Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Ras-effector interactions: after one decade.
@ast
Ras-effector interactions: after one decade.
@en
type
label
Ras-effector interactions: after one decade.
@ast
Ras-effector interactions: after one decade.
@en
prefLabel
Ras-effector interactions: after one decade.
@ast
Ras-effector interactions: after one decade.
@en
P1476
Ras-effector interactions: after one decade.
@en
P2093
Christian Herrmann
P304
P356
10.1016/S0959-440X(02)00007-6
P577
2003-02-01T00:00:00Z