The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim.
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The role of thyrotrophin receptor antibody assays in graves' diseaseBioassays for TSH Receptor Autoantibodies, from FRTL-5 Cells to TSH Receptor-LH/CG Receptor Chimeras: The Contribution of Leonard D. KohnBreaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunityReview and hypothesis: does Graves' disease develop in non-human great apes?Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy.Excessive Cytosolic DNA Fragments as a Potential Trigger of Graves' Disease: An Encrypted Message Sent by Animal ModelsImmune response of mice transgenic for human histocompatibility leukocyte Antigen-DR to human thyrotropin receptor-extracellular domainMechanisms of Autoantibody-Induced Pathology.Thyroid antigens, not central tolerance, control responses to immunization in BALB/c versus C57BL/6 mice.Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease.Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred miceExceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease.Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.Variable suppression of serum thyroxine in female mice of different inbred strains by triiodothyronine administered in drinking water.Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptorImmunoglobulin heavy chain variable region and major histocompatibility region genes are linked to induced graves' disease in females from two very large families of recombinant inbred miceAmino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid diseaseBreaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'.Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice.Crystal structure of a TSH receptor monoclonal antibody: insight into Graves' disease pathogenesis.Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological functionAn attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens.Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNAA unique mouse strain that develops spontaneous, iodine-accelerated, pathogenic antibodies to the human thyrotrophin receptor.Thyrotropin receptor autoantibodies (TSHRAbs): epitopes, origins and clinical significance.Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' DiseaseReceptor-activating autoantibodies and disease: preeclampsia and beyond.The genetic basis of graves' disease.Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells.Immunopathogenesis of Graves' ophthalmopathy: the role of the TSH receptor.Role of self-tolerance and chronic stimulation in the long-term persistence of adenovirus-induced thyrotropin receptor antibodies in wild-type and transgenic miceGenetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease.Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice.The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activationProbing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational formsShared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice.Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid functionTSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective.A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes.
P2860
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P2860
The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The thyrotropin receptor autoa ...... culprit as well as the victim.
@ast
The thyrotropin receptor autoa ...... culprit as well as the victim.
@en
type
label
The thyrotropin receptor autoa ...... culprit as well as the victim.
@ast
The thyrotropin receptor autoa ...... culprit as well as the victim.
@en
prefLabel
The thyrotropin receptor autoa ...... culprit as well as the victim.
@ast
The thyrotropin receptor autoa ...... culprit as well as the victim.
@en
P2093
P2860
P356
P1476
The thyrotropin receptor autoa ...... culprit as well as the victim.
@en
P2093
Chun-Rong Chen
Francesco Latrofa
Pavel Pichurin
Sandra M McLachlan
Yuji Nagayama
P2860
P304
P356
10.1172/JCI200317069
P407
P577
2003-06-01T00:00:00Z