DNA2 drives processing and restart of reversed replication forks in human cells. - Wikidata - thesis-toulmin - TriplyDB

DNA2 drives processing and restart of reversed replication forks in human cells.

DNA2 drives processing and restart of reversed replication forks in human cells.

http://www.wikidata.org/entity/Q35141202

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Replication-Associated Recombinational Repair: Lessons from Budding Yeast Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' Adducts The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy Replication stress: getting back on track Preventing replication fork collapse to maintain genome integrity A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions A balance between elongation and trimming regulates telomere stability in stem cells Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.Yet another job for Dna2: Checkpoint activation.A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery.TRAIP regulates replication fork recovery and progression via PCNA Sharpening the ends for repair: mechanisms and regulation of DNA resection.The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair.Mechanism and regulation of DNA end resection in eukaryotes Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability.Endonuclease EEPD1 Is a Gatekeeper for Repair of Stressed Replication Forks The Intra-S Checkpoint Responses to DNA Damage.EEPD1: Breaking and Rescuing the Replication Fork.Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.What is the DNA repair defect underlying Fanconi anemia?The essential kinase ATR: ensuring faithful duplication of a challenging genome.DNA replication stress: from molecular mechanisms to human disease.Protection or resection: BOD1L as a novel replication fork protection factor.Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest.WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress.Replication fork regression and its regulation.Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.

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DNA2 drives processing and restart of reversed replication forks in human cells.

http://www.wikidata.org/entity/Q35141202

description

2015 nî lūn-bûn

@nan

2015 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի մարտին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

DNA2 drives processing and restart of reversed replication forks in human cells.

@ast

DNA2 drives processing and restart of reversed replication forks in human cells.

@en

type

label

DNA2 drives processing and restart of reversed replication forks in human cells.

@ast

DNA2 drives processing and restart of reversed replication forks in human cells.

@en

prefLabel

DNA2 drives processing and restart of reversed replication forks in human cells.

@ast

DNA2 drives processing and restart of reversed replication forks in human cells.

@en

P1433

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P1433

Journal of Cell Biology

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DNA2 drives processing and restart of reversed replication forks in human cells

@en

P2093

Alessandro Vindigni

http://www.w3.org/2001/XMLSchema#string

Cosimo Pinto

http://www.w3.org/2001/XMLSchema#string

Eric A Hendrickson

http://www.w3.org/2001/XMLSchema#string

Eu Han Lee

http://www.w3.org/2001/XMLSchema#string

Hayley Moore

http://www.w3.org/2001/XMLSchema#string

Marko Vujanovic

http://www.w3.org/2001/XMLSchema#string

Massimo Lopes

http://www.w3.org/2001/XMLSchema#string

Matteo Berti

http://www.w3.org/2001/XMLSchema#string

Petr Cejka

http://www.w3.org/2001/XMLSchema#string

Ralph Zellweger

http://www.w3.org/2001/XMLSchema#string

P2860

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

Biochemical analysis of human Dna2

Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing.

Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity.

A yeast gene required for DNA replication encodes a protein with homology to DNA helicases.

A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

P304

545-562

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P31

scholarly article

P356

10.1083/JCB.201406100

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P433

5

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208

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Maryna Levikova

P577

2015-03-01T00:00:00Z

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P5875

273153332

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25733713

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P932

4347643

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