SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans - Wikidata - thesis-toulmin - TriplyDB

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

http://www.wikidata.org/entity/Q35183636

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Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration CXCR1/CXCR2 antagonist CXCL8(3-74)K11R/G31P blocks lung inflammation in swine barn dust-instilled mice Chemokine receptors and their therapeutic opportunities in diseased lung: far beyond leukocyte trafficking Genes of innate immunity and the biological response to inhaled ozone Neutrophils: Between host defence, immune modulation, and tissue injury Emerging targets in neuroinflammation-driven chronic pain The effect of environmental oxidative stress on airway inflammation Short-Term Associations between Air Pollution Concentrations and Respiratory Health-Comparing Primary Health Care Visits, Hospital Admissions, and Emergency Department Visits in a Multi-Municipality Study.The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers.Targeting IL-8 in colorectal cancer.Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2 Environmental effects on immune responses in patients with atopy and asthma.A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling.Characterization of the inflammatory response to inhaled lipopolysaccharide in mild to moderate chronic obstructive pulmonary disease.The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects.Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability.Trial Watch: Immunostimulatory cytokines.The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions The glutathione-S-transferase mu 1 (GSTM1) null genotype and increased neutrophil response to low-level ozone (0.06 ppm).Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways.Neutrophil adhesion molecules in experimental rhinovirus infection in COPD.Antibiotic and anti-inflammatory therapies for cystic fibrosis.Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist.International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.Neutrophil migration in infection and wound repair: going forward in reverse.The role of oxidative stress and innate immunity in O(3) and endotoxin-induced human allergic airway disease.Regulation of neutrophil trafficking from the bone marrow.Emerging drugs for chronic obstructive pulmonary disease.CXCR2 in acute lung injury.CXCR2: From Bench to Bedside.Challenge models to assess new therapies in chronic obstructive pulmonary disease.Longitudinal cystic fibrosis care.Flow cytometry: a flexible tool for biomarker research.Critical assessment of the value of sputum neutrophils.Pharmacological approaches to regulate neutrophil activity.New anti-inflammatory targets for chronic obstructive pulmonary disease.Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer.The mercurial nature of neutrophils: still an enigma in ARDS?CXCR2 modulators: a patent review (2009 - 2013).

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SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

http://www.wikidata.org/entity/Q35183636

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

SB-656933, a novel CXCR2 selec ...... airway inflammation in humans

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SB-656933, a novel CXCR2 selec ...... airway inflammation in humans

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SB-656933, a novel CXCR2 selec ...... airway inflammation in humans

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SB-656933, a novel CXCR2 selec ...... airway inflammation in humans

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SB-656933, a novel CXCR2 selec ...... airway inflammation in humans

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J.1365-2125.2011.03968.X

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British Journal of Clinical Pharmacology

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SB-656933, a novel CXCR2 selec ...... airway inflammation in humans

@en

P2093

Aili L Lazaar

http://www.w3.org/2001/XMLSchema#string

Alexander J MacDonald

http://www.w3.org/2001/XMLSchema#string

Chao Chen

http://www.w3.org/2001/XMLSchema#string

Lisa E Sweeney

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Neil E Alexis

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P2860

The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration

Human chemokines: an update

Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease

Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1

Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G

Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils.

Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects

Small molecule antagonists of the CXCR2 and CXCR1 chemokine receptors as therapeutic agents for the treatment of inflammatory diseases.

Fluticasone propionate protects against ozone-induced airway inflammation and modified immune cell activation markers in healthy volunteers.

The neutrophil in chronic obstructive pulmonary disease.

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282-293

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2

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Ruth Tal-Singer

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50807451

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21426372

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3162658

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