NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation - Wikidata - thesis-toulmin - TriplyDB

NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation

NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation

http://www.wikidata.org/entity/Q35184715

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1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes.Paramagnetic nuclear magnetic resonance relaxation and molecular mechanics studies of the chloroperoxidase-indole complex: insights into the mechanism of chloroperoxidase-catalyzed regioselective oxidation of indole The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.Validated HPLC determination of 4-dimethylaminoantipyrine in different suppository bases.An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.Spectroscopic studies of the cytochrome P450 reaction mechanisms.Redox inactive metal ion triggered N-dealkylation by an iron catalyst with dioxygen activation: a lesson from lipoxygenases.

P2860

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P2860

NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation

http://www.wikidata.org/entity/Q35184715

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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NMR-derived models of amidopyr ...... m of sequential N-dealkylation

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NMR-derived models of amidopyr ...... m of sequential N-dealkylation

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NMR-derived models of amidopyr ...... m of sequential N-dealkylation

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NMR-derived models of amidopyr ...... m of sequential N-dealkylation

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Adah Almutairi

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Arthur G Roberts

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James R Halpert

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Kathy T Vu

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Nadezda Fomina

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Sara E A Sjögren

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P2860

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution

An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution

Structural and Thermodynamic Consequences of 1-(4-Chlorophenyl)imidazole Binding to Cytochrome P450 2B4 † , ‡

Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,

Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

GROMACS: fast, flexible, and free

Evaluation of site-directed spin labeling for characterizing protein-ligand complexes using simulated restraints.

Molecular basis for the differences in lidocaine binding and regioselectivity of oxidation by cytochromes P450 2B1 and 2B2

Prediction of 1H NMR Chemical Shifts Using Neural Networks

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10.1021/BI101797V

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12

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