ECSASB2 mediates MLL degradation during hematopoietic differentiation - Wikidata - thesis-toulmin - TriplyDB

ECSASB2 mediates MLL degradation during hematopoietic differentiation

ECSASB2 mediates MLL degradation during hematopoietic differentiation

http://www.wikidata.org/entity/Q35750333

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Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4 Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways Hijacked in cancer: the KMT2 (MLL) family of methyltransferases Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer Filamins but not Janus kinases are substrates of the ASB2α cullin-ring E3 ubiquitin ligase in hematopoietic cells.The MLL recombinome of acute leukemias in 2013.The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.Ectopic expression of homeobox gene NKX2-1 in diffuse large B-cell lymphoma is mediated by aberrant chromatin modifications.CAWS administration increases the expression of interferon γ and complement factors that lead to severe vasculitis in DBA/2 mice A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells.The SOCS box-adapting proteins for ubiquitination and proteasomal degradation.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Mechanisms of mixed-lineage leukemia.The MLL recombinome of acute leukemias in 2017.Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins.Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.N6-methyladenosine links RNA metabolism to cancer progression.FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.N6-methyladenine RNA modification and cancers The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells

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P2860

ECSASB2 mediates MLL degradation during hematopoietic differentiation

http://www.wikidata.org/entity/Q35750333

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

ECSASB2 mediates MLL degradation during hematopoietic differentiation

@ast

ECSASB2 mediates MLL degradation during hematopoietic differentiation

@en

type

label

ECSASB2 mediates MLL degradation during hematopoietic differentiation

@ast

ECSASB2 mediates MLL degradation during hematopoietic differentiation

@en

prefLabel

ECSASB2 mediates MLL degradation during hematopoietic differentiation

@ast

ECSASB2 mediates MLL degradation during hematopoietic differentiation

@en

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P1476

ECSASB2 mediates MLL degradation during hematopoietic differentiation

@en

P2093

Andrew G Muntean

http://www.w3.org/2001/XMLSchema#string

Jay L Hess

http://www.w3.org/2001/XMLSchema#string

Jingya Wang

http://www.w3.org/2001/XMLSchema#string

P2860

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

Functional analysis of Asb-1 using genetic modification in mice

The role of human bromodomains in chromatin biology and gene transcription

Molecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM Domain

The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .

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1151-1161

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scholarly article

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10.1182/BLOOD-2011-06-362079

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5

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119

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2011-12-15T00:00:00Z

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51884121

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22174154

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3277351

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