Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates.
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Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplicationEvolution of Gene Duplication in PlantsA branch-heterogeneous model of protein evolution for efficient inference of ancestral sequencesComputational protein engineering: bridging the gap between rational design and laboratory evolution.The rise of chemodiversity in plants.Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustnessProbing impact of active site residue mutations on stability and activity of Neisseria polysaccharea amylosucrase.Network-level architecture and the evolutionary potential of underground metabolism.Out of fuzzy chemistry: from prebiotic chemistry to metabolic networks.Escherichia coli D-malate dehydrogenase, a generalist enzyme active in the leucine biosynthesis pathwayConvergent evolution of caffeine in plants by co-option of exapted ancestral enzymes.Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases.Insights into the evolution of enzyme substrate promiscuity after the discovery of (βα)₈ isomerase evolutionary intermediates from a diverse metagenome.Computational Identification of Amino-Acid Mutations that Further Improve the Activity of a Chalcone-Flavonone Isomerase from Glycine maxStabilization of different types of transition states in a single enzyme active site: QM/MM analysis of enzymes in the alkaline phosphatase superfamily.Dynamics and constraints of enzyme evolution.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Evidence that Environmental Heterogeneity Maintains a Detoxifying Enzyme Polymorphism in Drosophila melanogaster.Experimental recreation of the evolution of lignin-degrading enzymes from the Jurassic to date.Modeling catalytic promiscuity in the alkaline phosphatase superfamily.Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases.The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases.A novel methyltransferase from the intracellular pathogen Plasmodiophora brassicae methylates salicylic acid.The evolutionary appearance of non-cyanogenic hydroxynitrile glucosides in the Lotus genus is accompanied by the substrate specialization of paralogous β-glucosidases resulting from a crucial amino acid substitution.Evolution and Function of the Populus SABATH Family Reveal That a Single Amino Acid Change Results in a Substrate Switch.Evolution of protein specificity: insights from ancestral protein reconstruction.Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity.Subcellular Relocalization and Positive Selection Play Key Roles in the Retention of Duplicate Genes of Populus Class III Peroxidase Family.Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset
P2860
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P2860
Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Enzyme functional evolution th ...... rally nonpreferred substrates.
@ast
Enzyme functional evolution th ...... rally nonpreferred substrates.
@en
type
label
Enzyme functional evolution th ...... rally nonpreferred substrates.
@ast
Enzyme functional evolution th ...... rally nonpreferred substrates.
@en
prefLabel
Enzyme functional evolution th ...... rally nonpreferred substrates.
@ast
Enzyme functional evolution th ...... rally nonpreferred substrates.
@en
P2093
P2860
P356
P1476
Enzyme functional evolution th ...... rally nonpreferred substrates.
@en
P2093
Birgit Piechulla
Diana Rohrbeck
Frank Hippauf
Janie Feike
Katrin Wenke
Maria Haustein
Noah Sorrelle
Ruiqi Huang
Todd J Barkman
P2860
P304
P356
10.1073/PNAS.1019605109
P407
P577
2012-02-06T00:00:00Z