The Interplay between Alpha-Synuclein Clearance and Spreading - Wikidata - thesis-toulmin - TriplyDB

The Interplay between Alpha-Synuclein Clearance and Spreading

The Interplay between Alpha-Synuclein Clearance and Spreading

http://www.wikidata.org/entity/Q35833984

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Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease Bifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ.α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease Blood Plasma of Patients with Parkinson's Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity.Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Treatments and compositions targeting α-synuclein: a patent review (2010-2016).The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease.From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models Upregulation of autophagy-related gene 5 protects dopaminergic neurons in a zebrafish model of Parkinson's disease.A pH-dependent switch promotes β-synuclein fibril formation via glutamate residues.Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells The Molecular Physiopathogenesis of Islet Amyloidosis.Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson's disease.Parkinson's Disease Is Not Simply a Prion Disorder.Alpha-synuclein, proteotoxicity and Parkinson's disease: Search for neuroprotective therapy.Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization.Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's Disease.Association of exercise-induced autophagy upregulation and apoptosis suppression with neuroprotection against pharmacologically induced Parkinson's disease.Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy.

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P2860

The Interplay between Alpha-Synuclein Clearance and Spreading

http://www.wikidata.org/entity/Q35833984

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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The Interplay between Alpha-Synuclein Clearance and Spreading

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The Interplay between Alpha-Synuclein Clearance and Spreading

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The Interplay between Alpha-Synuclein Clearance and Spreading

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The Interplay between Alpha-Synuclein Clearance and Spreading

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Anna Villar-Piqué

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Tiago Fleming Outeiro

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Tomás Lopes da Fonseca

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Creative Commons Attribution

P2860

The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3

Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization

Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p

HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.

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10.3390/BIOM5020435

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2

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276115434

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25874605

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Parkinson's disease

nerve tissue proteins

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