Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging
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Human conditions of insulin-like growth factor-I (IGF-I) deficiencyMitochondria and cardiovascular agingNADPH oxidases: key modulators in aging and age-related cardiovascular diseases?HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agentsTesting the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?Cerebral microhemorrhages: mechanisms, consequences, and prevention.Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease.Insulin-like growth factor 1 physiology: lessons from mouse models.Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.Determination of the total mass of antioxidant substances and antioxidant capacity per unit mass in serum using redox titration.Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.Insulin-like growth factor-1 regulates glutathione peroxidase expression and activity in vascular endothelial cells: Implications for atheroprotective actions of insulin-like growth factor-1.Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea stagnalis).Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive miceEndothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.Reductions in serum IGF-1 during aging impair health span.Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular agingThe emerging role of IGF-1 deficiency in cardiovascular aging: recent advancesAging, atherosclerosis, and IGF-1Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular agingAge-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.Diverging antioxidative responses to IGF-1 in cultured human skin fibroblasts versus vascular endothelial cells.SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype?Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation.Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future ResearchSynergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease.
P2860
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P2860
Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Liver-specific knockdown of IG ...... novel model of vascular aging
@ast
Liver-specific knockdown of IG ...... novel model of vascular aging
@en
type
label
Liver-specific knockdown of IG ...... novel model of vascular aging
@ast
Liver-specific knockdown of IG ...... novel model of vascular aging
@en
prefLabel
Liver-specific knockdown of IG ...... novel model of vascular aging
@ast
Liver-specific knockdown of IG ...... novel model of vascular aging
@en
P2093
P2860
P356
P1476
Liver-specific knockdown of IG ...... novel model of vascular aging
@en
P2093
Akos Koller
Anna Csiszar
Caroline Bass
Danuta Sosnowska
Jim C Henthorn
John T Pinto
Julie Farley
Lora C Bailey-Downs
M Noa Valcarcel-Ares
Matthew Mitschelen
P2860
P304
P356
10.1093/GERONA/GLR164
P407
P577
2011-10-21T00:00:00Z