Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
about
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemiaNotch signaling in CD4 and CD8 T cell developmentModeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1.Cell of origin strongly influences genetic selection in a mouse model of T-ALLp16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment.Synergy between the pre-T cell receptor and Notch: cementing the alphabeta lineage choice.Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.New treatments for chronic lymphocytic leukemia.Regulation of immune responses and tolerance: the microRNA perspective.Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1Notch signaling in leukemia.Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia.Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises.Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.A TCR-switchable cell death pathway in T-ALL.Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.Leukemia-initiating cell activity requires calcineurin in T-cell acute lymphoblastic leukemia.Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides.
P2860
Q24632890-A5717D32-3656-4801-91E2-E2D0DFCCB1A8Q24656638-E3B79685-ECE9-4B78-97C4-142A39EE3F9DQ33885674-7D0447C4-A299-426C-B43F-BFB64B40CA9AQ34390573-78AAF120-0CA7-47FA-A48A-A11BFCE98861Q35525387-DA1C2298-66F3-4D6F-9508-E3A53BB6D6B9Q36007595-1AD87DB7-203E-4E6E-9ACB-5E86400B4B3AQ36228639-81C3A8F2-802B-4224-AA06-ECEE568A697CQ36238113-F21E6D03-E2F6-4815-BC1D-A09CD0BDEBEAQ36603732-7FA44BC3-C1D7-49CF-871F-7D8F7EDEE5CFQ36610031-585612DF-9712-4050-8378-5E919B0BC152Q36685371-E91D4BA9-D40D-4423-A951-99AC42F2CE57Q36913232-569CA2F7-3948-4EA8-A7D4-433F788DDE0FQ36934845-49FC80AB-DFA4-4C5F-9208-63C02F0BAF43Q36979929-055699CC-2EE1-46D0-B13D-A7814BBC9C3CQ37014817-8A3C7D89-8DCB-4B1F-99D3-E9F653966433Q37272317-8CAC5852-6184-43AE-95E8-AB08647185D2Q37861191-0C3D3225-9A60-4902-B861-4D2ED72D88ADQ37934968-7CC655AD-429C-41CF-A069-B9D3BF00E3CBQ38125650-A47A9C62-67A8-4376-84D5-526AF2BA7F65Q40195204-7B9B3B87-2427-4567-B559-A546A580C078Q42061814-950AFA78-CFE8-43B8-B89C-D51D66AA9E55Q42347552-891BCC2A-3A46-4D24-B0D2-558377E194EDQ42542192-8F6FE76F-E71D-4A5F-BD8B-584163EB94CEQ50978065-5F04889D-4A7C-419B-9E1D-C6A45FBE44EFQ54108534-98C33A09-48FE-4B8D-9338-663C08D5DC0A
P2860
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Notch1-dependent lymphomagenes ...... ally require pre-TCR signaling
@ast
Notch1-dependent lymphomagenes ...... ally require pre-TCR signaling
@en
type
label
Notch1-dependent lymphomagenes ...... ally require pre-TCR signaling
@ast
Notch1-dependent lymphomagenes ...... ally require pre-TCR signaling
@en
prefLabel
Notch1-dependent lymphomagenes ...... ally require pre-TCR signaling
@ast
Notch1-dependent lymphomagenes ...... ally require pre-TCR signaling
@en
P2093
P2860
P1433
P1476
Notch1-dependent lymphomagenes ...... ally require pre-TCR signaling
@en
P2093
Annette I Garbe
Fangrong Zhang
Harald von Boehmer
Isabella Screpanti
P2860
P304
P356
10.1182/BLOOD-2006-01-0143
P407
P577
2006-02-28T00:00:00Z